Email this article Synthesis and antiproliferative activity of 2-aryl-aminopyrimidine amides of benzimidazole-substituted phenylcarboxylic acid – new potential protein kinase inhibitors
- Authors: Koroleva E.V.1, Ermolinskaya A.L.1, Ignatovich Z.V.1, Panibrat O.V.2, Hoang T.3, Huynh T.3, Nguyen T.3
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Affiliations:
- Institute of Chemistry of New Materials, NAS of Belarus
- Institute of Bioorganic Chemistry, NAS of Belarus
- Institute of Chemical Technology, Vietnam Academy of Science and Technology
- Issue: Vol 61, No 2 (2025)
- Pages: 159-166
- Section: Articles
- URL: https://clinpractice.ru/0514-7492/article/view/684319
- DOI: https://doi.org/10.31857/S0514749225020053
- EDN: https://elibrary.ru/DGIXKF
- ID: 684319
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Abstract
The results of a study on the synthesis and antiproliferative activity of new phenylcarboxylic acid amides, the structure of which contains pharmacophoric fragments of nitrogen-containing heterocycles – 2-aminopyrimidine, benzimidazole, pyridine, are presented. The synthesis was carried out by acylation of substituted 2-arylaminopyrimidine phenylenediamines with p-benzimidazole-phenylcarboxylic acid chloride or by aminolysis of p-benzimidazolephenylcarboxylic acid with 2-arylaminopyrimidinephenylenediamines. The potential inhibitory activity of the synthesized amides was assessed by in vitro screening of the compounds for antiproliferative activity in models of stable human tumor cell lines K562, HL-60, RPMI 1788, HeLa.
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About the authors
E. V. Koroleva
Institute of Chemistry of New Materials, NAS of Belarus
Author for correspondence.
Email: evk@ichnm.by
ORCID iD: 0000-0002-0300-8011
Belarus, ul. F. Skoriny, 36, Minsk, 220084
A. L. Ermolinskaya
Institute of Chemistry of New Materials, NAS of Belarus
Email: evk@ichnm.by
ORCID iD: 0000-0002-7228-1900
Belarus, ul. F. Skoriny, 36, Minsk, 220084
Zh. V. Ignatovich
Institute of Chemistry of New Materials, NAS of Belarus
Email: evk@ichnm.by
ORCID iD: 0000-0003-0259-4140
Belarus, ul. F. Skoriny, 36, Minsk, 220084
O. V. Panibrat
Institute of Bioorganic Chemistry, NAS of Belarus
Email: evk@ichnm.by
ORCID iD: 0000-0001-7896-4430
Belarus, ul. Kuprevicha, 5, Minsk, 220084
Thi-Kim-Dung Hoang
Institute of Chemical Technology, Vietnam Academy of Science and Technology
Email: evk@ichnm.by
Viet Nam, No.1A, Thanh Loc Street, Thanh Loc Ward, District 12, Ho Chi Minh City, 70000
Thi-Kim-Chi Huynh
Institute of Chemical Technology, Vietnam Academy of Science and Technology
Email: evk@ichnm.by
Viet Nam, No.1A, Thanh Loc Street, Thanh Loc Ward, District 12, Ho Chi Minh City, 70000
Thi-Cam-Thu Nguyen
Institute of Chemical Technology, Vietnam Academy of Science and Technology
Email: evk@ichnm.by
Viet Nam, No.1A, Thanh Loc Street, Thanh Loc Ward, District 12, Ho Chi Minh City, 70000
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