Synthesis and Properties of 1,3-Disubstituted Ureas and Its Isosteric Analogs Containing Polycyclic Fragments: XVIII. 1-[2-(Adamantan-2-yl)ethyl]-3-R-Ureas and Thioureas

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Methods for the preparation of 1-[2-(adamantan-2-yl)ethyl]-3-R-ureas and thioureas by the reaction of 2-(adamantan-2-yl)ethylamine with aromatic isocyanates and isothiocyanates with 36–87% yields were developed. It was found that the displacement of the ethylene bridge from the 1st to the 2nd position of the adamantyl radical does not significantly affect the value of log P and melting points of the corresponding compounds.

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作者简介

V. Burmistrov

Volgograd State Technical University (VSTU)

编辑信件的主要联系方式.
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-8547-9166
俄罗斯联邦, Volgograd

D. Zapravdina

Volgograd State Technical University (VSTU)

Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-8654-2382
俄罗斯联邦, Volzhsky

E. Savelyev

Volgograd State Technical University (VSTU)

Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-1937-768X
俄罗斯联邦, Volgograd

B. Orlinson

Volgograd State Technical University (VSTU)

Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-4710-4718
俄罗斯联邦, Volgograd

G. Butov

Volgograd State Technical University (VSTU); Volzhsky Polytechnic Institute (branch) VSTU

Email: butov@post.volpi.ru
ORCID iD: 0000-0002-0839-4513
俄罗斯联邦, Volgograd; Volzhsky

I. Novakov

Volgograd State Technical University (VSTU)

Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-0980-6591
俄罗斯联邦, Volgograd

参考

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2. Compounds containing 2-(adamantan-2-yl)ethyl fragments exhibiting biological activity

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3. Scheme 1

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4. Scheme 2

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5. Scheme 3

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