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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Clinical Practice</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Clinical Practice</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническая практика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2220-3095</issn><issn publication-format="electronic">2618-8627</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">10627</article-id><article-id pub-id-type="doi">10.17816/clinpract9447-54</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original Study Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The influence of etiological factors on immunoreactivity in patients with community-acquired pneumonia</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние этиологических факторов на иммунореактивность у пациентов с внебольничной пневмонией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="scopus">24391582000</contrib-id><contrib-id contrib-id-type="researcherid">E-9258-2014</contrib-id><contrib-id contrib-id-type="spin">5267-9598</contrib-id><name-alternatives><name xml:lang="en"><surname>Rvacheva</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Рвачёва</surname><given-names>Анна Валерьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>канд. мед. наук, заведующая лабораторией иммунологии; ведущий науч. сотр. лаборатории пульмонологии отдела клинической медицины </p></bio><email>arvatcheva@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pustovalov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Пустовалов</surname><given-names>Алексей Алексеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>канд. мед. наук, научный сотрудник лаборатории пульмонологии отдела клинической медицины</p></bio><email>apoustovalov@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="scopus">26538429700</contrib-id><contrib-id contrib-id-type="researcherid">E-9177-2014</contrib-id><name-alternatives><name xml:lang="en"><surname>Zykov</surname><given-names>K. A.</given-names></name><name xml:lang="ru"><surname>Зыков</surname><given-names>Кирилл Алексеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>kirillaz@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Institute of Pulmonology of the Federal Medical-Biological Agency of Russia</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт пульмонологии Федерального медико-биологического агентства России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Moscow State University of Medicine and Dentistry a.n. A.I. Evdokimov</institution></aff><aff><institution xml:lang="ru">Московский государственный медико-стоматологический университет имени А.И. Евдокимова</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2018</year></pub-date><volume>9</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru">Клиническая практика</issue-title><fpage>47</fpage><lpage>54</lpage><history><date date-type="received" iso-8601-date="2018-12-05"><day>05</day><month>12</month><year>2018</year></date><date date-type="accepted" iso-8601-date="2018-12-06"><day>06</day><month>12</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Rvacheva A.V., Pustovalov A.A., Zykov K.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Рвачёва А.В., Пустовалов А.А., Зыков К.А.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Rvacheva A.V., Pustovalov A.A., Zykov K.A.</copyright-holder><copyright-holder xml:lang="ru">Рвачёва А.В., Пустовалов А.А., Зыков К.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://clinpractice.ru/clinpractice/article/view/10627">https://clinpractice.ru/clinpractice/article/view/10627</self-uri><abstract xml:lang="en"><p><bold> </bold>The aim of this study was to uncover the characteristics of immunoreactivity in patients with community-acquired pneumonia, depending on the pathogen. The inflammatory process caused by various pathogens, has its own characteristics and affects the course of the disease. The study of the mechanisms of these complex interactions can improve the understanding of the processes occurring in community-acquired pneumonia, and, therefore, develop individual approaches to the therapy depending on the etiological factor.</p></abstract><trans-abstract xml:lang="ru"><p>Целью настоящего исследования было изучение особенностей иммунореактивности у пациентов с внебольничной пневмонией в зависимости от возбудителя. Воспалительный процесс, вызываемый различными возбудителями, имеет свои особенности и влияет на течение заболевания. Изучение механизмов данного комплексного взаимодействия может улучшить понимание процессов, происходящих при внебольничной пневмонии, а следовательно, разработать индивидуальные подходы к терапии в зависимости от этиологического фактора.</p></trans-abstract><kwd-group xml:lang="en"><kwd>community-acquired pneumonia</kwd><kwd>etiological factor</kwd><kwd>immunoreactivity</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>внебольничная пневмония</kwd><kwd>этиологический фактор</kwd><kwd>иммунореактивность</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека. Инфекционная заболеваемость в Российской Федерации за январь-декабрь 2017 г. Доклад от 15.05.2018. Сведения об инфекционных и паразитарных заболеваниях за январь-декабрь 2017 г. [Federal’naya sluzhba po nadzoru v sfere zashchity prav potrebitelej i blagopoluchiya cheloveka. 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