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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Clinical Practice</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Clinical Practice</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническая практика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2220-3095</issn><issn publication-format="electronic">2618-8627</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">107997</article-id><article-id pub-id-type="doi">10.17816/clinpract107997</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Aspergillosis of the brain: diagnostic difficulties. Case report</article-title><trans-title-group xml:lang="ru"><trans-title>Аспергиллез головного мозга: трудности диагностики. Клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6294-1776</contrib-id><contrib-id contrib-id-type="spin">7776-4134</contrib-id><name-alternatives><name xml:lang="en"><surname>Verbakh</surname><given-names>Tatyana E.</given-names></name><name xml:lang="ru"><surname>Вербах</surname><given-names>Татьяна Эдуардовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>shtork@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7598-7757</contrib-id><contrib-id contrib-id-type="spin">3162-0770</contrib-id><name-alternatives><name xml:lang="en"><surname>Kicherova</surname><given-names>Oksana A.</given-names></name><name xml:lang="ru"><surname>Кичерова</surname><given-names>Оксана Альбертовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Assistant Professor</p></bio><bio xml:lang="ru"><p>д.м.н., доцент</p></bio><email>pan1912@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4313-0836</contrib-id><contrib-id contrib-id-type="spin">1703-2302</contrib-id><name-alternatives><name xml:lang="en"><surname>Reihert</surname><given-names>Lyudmila I.</given-names></name><name xml:lang="ru"><surname>Рейхерт</surname><given-names>Людмила Ивановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>lir0806@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1176-4113</contrib-id><contrib-id contrib-id-type="spin">6877-6140</contrib-id><name-alternatives><name xml:lang="en"><surname>Ostapchuk</surname><given-names>Ekaterina S.</given-names></name><name xml:lang="ru"><surname>Остапчук</surname><given-names>Екатерина Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ostapchuk2008@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Tyumen State Medical University</institution></aff><aff><institution xml:lang="ru">Тюменский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2022-10-04" publication-format="electronic"><day>04</day><month>10</month><year>2022</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-01-24" publication-format="electronic"><day>24</day><month>01</month><year>2023</year></pub-date><volume>13</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>88</fpage><lpage>92</lpage><history><date date-type="received" iso-8601-date="2022-05-17"><day>17</day><month>05</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-09-08"><day>08</day><month>09</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://clinpractice.ru/clinpractice/article/view/107997">https://clinpractice.ru/clinpractice/article/view/107997</self-uri><abstract xml:lang="en"><p><bold>Background:</bold> Neuroaspergillosis has nonspecific clinical manifestations and a severe course. Cases of central nervous system aspergillosis are becoming more frequent. Its lifetime diagnosis is very difficult. At the same time, a timely diagnosis makes it possible to conduct an adequate specific therapy and save the patient's life.</p> <p><bold>Clinical case description:</bold> We report a clinical case of a patient with a lethal damage to the brain by filamentous fungi, who did not have the risk factors described in the literature — human immunodeficiency virus (HIV), neutropenia, organ and tissue transplantation, long therapy with immunosuppressive drugs or corticosteroids.</p> <p><bold>Conclusion:</bold> One needs to consider a possibility of this pathology in patients even in the absence of a fever and immunodeficiency conditions. A specific study of biological fluids for the presence of the galactomannan antigen may allow one to establish a timely correct diagnosis and apply an adequate treatment.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Аспергиллез центральной нервной системы характеризуется тяжелым течением и неспецифическими клиническими проявлениями, затрудняющими его прижизненную диагностику. При этом своевременная постановка диагноза позволяет провести адекватную специфическую терапию и спасти жизнь пациента.</p> <p><bold>Описание клинического случая.</bold> Представлен клинический случай летального поражения нитчатыми грибами головного мозга у пациента, не имеющего описанных в литературе факторов риска — ВИЧ-инфекции, нейтропении, трансплантации органов и тканей, длительной терапии иммуносупрессивными препаратами или глюкокортикоидами.</p> <p><bold>Заключение.</bold> Необходимо учитывать наличие данной патологии у больных даже в отсутствии лихорадки и иммунодефицитных состояний. Специфическое исследование биологических жидкостей на содержание галактоманнанового антигена позволит вовремя установить верный диагноз и провести адекватное лечение.</p></trans-abstract><kwd-group xml:lang="en"><kwd>aspergillosis</kwd><kwd>neuroaspergillosis</kwd><kwd>case report</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аспергиллез</kwd><kwd>аспергиллез головного мозга</kwd><kwd>микозы центральной нервной системы</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Кораблина И.М., Цинзерлинг В.А., Аравийский Р.А. Аспергиллез по данным аутопсий в Ленинградской областной клинической больнице с 2001 по 2010 гг. // Проблемы медицинской микологии. 2011. Т. 13, № 2. С. 45–46. [Korablina IM, Tsinserling VA, Araviysky RA. Aspergillosis according to autopsies in the Leningrad regional clinical hospital from 2001 to 2010. Problems Medical Mycology. 2011;13(2):45–46. 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