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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Clinical Practice</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Clinical Practice</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническая практика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2220-3095</issn><issn publication-format="electronic">2618-8627</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">114816</article-id><article-id pub-id-type="doi">10.17816/clinpract114816</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original Study Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Magnetic resonance imaging in the diagnosis of myocarditis in children</article-title><trans-title-group xml:lang="ru"><trans-title>Магнитно-резонансная томография в диагностике миокардитов у детей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3838-3284</contrib-id><contrib-id contrib-id-type="spin">1298-8350</contrib-id><name-alternatives><name xml:lang="en"><surname>Fomina</surname><given-names>Lyubov E.</given-names></name><name xml:lang="ru"><surname>Фомина</surname><given-names>Любовь Евгеньевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>love.fomina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1272-5119</contrib-id><contrib-id contrib-id-type="spin">5591-8066</contrib-id><name-alternatives><name xml:lang="en"><surname>Yarmola</surname><given-names>Igor I.</given-names></name><name xml:lang="ru"><surname>Ярмола</surname><given-names>Игорь Игоревич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>lord_Dukich@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1267-1517</contrib-id><name-alternatives><name xml:lang="en"><surname>Barskiy</surname><given-names>Vladimir I.</given-names></name><name xml:lang="ru"><surname>Барский</surname><given-names>Владимир Ильич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>woowka@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="spin">7592-1352</contrib-id><name-alternatives><name xml:lang="en"><surname>Anikin</surname><given-names>Anatoly V.</given-names></name><name xml:lang="ru"><surname>Аникин</surname><given-names>Анатолий Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>anikacor@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Uglova</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Углова</surname><given-names>Елена Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>uglova8@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">National Medical Research Center for Children’s Health</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр здоровья детей</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-07-02" publication-format="electronic"><day>02</day><month>07</month><year>2023</year></pub-date><volume>14</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>28</fpage><lpage>35</lpage><history><date date-type="received" iso-8601-date="2022-11-23"><day>23</day><month>11</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2023-04-30"><day>30</day><month>04</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://clinpractice.ru/clinpractice/article/view/114816">https://clinpractice.ru/clinpractice/article/view/114816</self-uri><abstract xml:lang="en"><p><bold>Background:</bold> There is a need for the systematization, generalization and analysis of the structural changes of the myocardium, occurring in patients with myocarditis. This disease is rare; therefore, structured information in the field of radiological diagnostics is still insufficient within national publications.</p> <p><bold>Aim:</bold> The study purpose was to determine the significance and specificity of changes observed in cardiac magnetic resonance images in patients with myocarditis, and to compare the obtained results with the literature data.</p> <p><bold>Methods:</bold> 7 patients, including children aged 4 and 6, with a verified diagnosis of myocarditis were retrospectively examined.</p> <p><bold>Results:</bold> The analysis of the obtained images revealed the most common changes related to myocarditis, such as myocardial edema, impaired myocardial contractility, increased delayed accumulation of the contrast agent. The pathophysiological mechanisms of the found structural changes were analyzed and described.</p> <p><bold>Conclusion:</bold> Magnetic resonance imaging is the most important non-invasive method for diagnosing myocarditis, which allows one to identify the lesion of the heart muscle, to assess the extent of its damage, to differentiate myocarditis from other diseases, as well as to assess the dynamics when evaluating the effectiveness of therapy.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Необходимы систематизация, обобщение и анализ структурных изменений миокарда, возникающих у пациентов с миокардитом. Данное заболевание является редкой нозологией, поэтому среди отечественных публикаций сохраняется недостаток структурированной информации в области лучевой диагностики.</p> <p><bold>Цель исследования</bold> — определение значимости и специфичности изменений при анализе результатов магнитно-резонансной томографии сердца у пациентов с миокардитами и их сопоставление с данными литературы.</p> <p><bold>Методы.</bold> Ретроспективно обследованы 7 пациентов, включая детей в возрасте 4 и 6 лет, с верифицированным диагнозом миокардита.</p> <p><bold>Результаты.</bold> При анализе полученных изображений выявлены наиболее распространённые изменения, такие как отёк миокарда, нарушение сократимости миокарда, повышенное накопление контрастного препарата в отсроченные фазы. Проанализированы и описаны патофизиологические механизмы возникновения структурных изменений.</p> <p><bold>Заключение.</bold> Магнитно-резонансная томография является важнейшим неинвазивным методом диагностики миокардита, позволяющим выявить поражение сердечной мышцы, оценить степень её повреждения, дифференцировать миокардит с другими заболеваниями, а также оценить динамику при оценке эффективности терапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>myocarditis</kwd><kwd>magnetic resonance imaging</kwd><kwd>fibrosis</kwd><kwd>myocardial edema</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>миокардит</kwd><kwd>магнитно-резонансная томография</kwd><kwd>фиброз</kwd><kwd>отёк миокарда</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Chow LH, Radio SJ, Sears TD, McManus BM. Insensitivity of right ventricular endomyocardial biopsy in the diagnosis of myocarditis. J Am Coll Cardiol. 1989;14(4):915–920. doi: 10.1016/0735-1097(89)90465-8</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Gutberlet M, Spors B, Thoma T, et al. Suspected chronic myocarditis at cardiac MR: Diagnostic accuracy and association with immunohistologically detected inflammation and viral persistence. Radiology. 2008;246(2):401–409. doi: 10.1148/radiol.2461062179</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Mangin M, Mahrholdt H, Sechtem U. [Diagnosis of myocarditis: Description and assessment of available methods. (In German)]. Dtsch Med Wochenschr. 2006;131(21):1228–1234. doi: 10.1055/s-2006-941758</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Mahrholdt H, Goedecke C, Wagner A, et al. Cardiovascular magnetic resonance assessment of human myocarditis: A comparison to histology and molecular pathology. Circulation. 2004; 109(10):1250–1258. doi: 10.1161/01.CIR.0000118493.13323.81</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Pan JA, Lee YJ, Salerno M. Diagnostic performance of extracellular volume, native T1, and T2 mapping versus lake louise criteria by cardiac magnetic resonance for detection of acute myocarditis: A meta-analysis. Circ Cardiovasc Imaging. 2018;11(7):e007598. doi: 10.1161/CIRCIMAGING.118.007598</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Ferreira VM, Schulz-Menger J, Holmvang G, et al. Cardiovascular magnetic resonance in nonischemic myocardial inflammation: Expert recommendations. J Am Coll Cardiol. 2018;72(24): 3158–3176. doi: 10.1016/j.jacc.2018.09.072</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Luetkens JA, Faron A, Isaak A, et al. Comparison of original and 2018 lakе louise criteria for diagnosis of acute myocarditis: Results of a validation cohort. Radiol Cardiothorac Imaging. 2019;1(3):e190010. doi: 10.1148/ryct.2019190010</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Radunski UK, Lund GK, Stehning C, et al. CMR in patients with severe myocarditis: Diagnostic value of quantitative tissue markers including extracellular volume imaging. JACC Cardiovasc Imaging. 2014;7(7):667–675. doi: 10.1016/j.jcmg.2014.02.005</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Von Knobelsdorff-Brenkenhoff F, Schuler J, Doganguzel S, et al. Detection and monitoring of acute myocarditis applying quantitative cardiovascular magnetic resonance. Circ Cardiovasc Imaging. 2017;10(2):e005242. doi: 10.1161/circimaging.116.005242</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Luetkens JA, Homsi R, Sprinkart AM, et al. Incremental value of quantitative CMR including parametric mapping for the diagnosis of acute myocarditis. Eur Heart J Cardiovasc Imaging. 2016;17(2):154–161. doi: 10.1093/ehjci/jev246</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Friedrich MG, Sechtem U, Schulz-Menger J, et al. Cardiovascular magnetic resonance in myocarditis: A jacc white paper. J Am Coll Cardiol. 2009;53(17):1475–1487. doi: 10.1016/j.jacc.2009.02.007</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Eitel I, von Knobelsdorff-Brenkenhoff F, Bernhardt P, et al. Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy. JAMA. 2011; 306(3):277–286. doi: 10.1001/jama.2011.992</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Dall’Armellina E, Piechnik SK, Ferreira VM, et al. Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of severity of injury in acute myocardial infarction. J Cardiovasc Magn Reson. 2012;14(1):15. doi: 10.1186/1532-429X-14-15</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Blauwet LA, Cooper LT. Myocarditis. Prog Cardiovasc Dis. 2010;52(4):274–288. doi: 10.1016/j.pcad.2009.11.006</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Bami K, Haddad T, Dick A, et al. Noninvasive imaging in acute myocarditis. Curr Opin Cardiol. 2016;31(2):217–223. doi: 10.1097/HCO.0000000000000265</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Angelini A, Calzolari V, Calabrese F, et al. Myocarditis mimicking acute myocardial infarction: Role of endomyocardial biopsy in the differential diagnosis. Heart. 2000;84(3):245–250. doi: 10.1136/heart.84.3.245</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Alexander PM, Daubeney PE, Nugent AW, et al.; National Australian Childhood Cardiomyopathy Study. Long-term outcomes of dilated cardiomyopathy diagnosed during childhood: Results from a national population-based study of childhood cardiomyopathy. Circulation. 2013;128(18):2039–2046. doi: 10.1161/circulationaha.113.002767</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Foerster SR, Canter CE, Cinar A, et al. Ventricular remodeling and survival are more favorable for myocarditis than for idiopathic dilated cardiomyopathy in childhood: An outcomes study from the Pediatric Cardiomyopathy Registry. Circ Heart Fail. 2010;3(6):689–697. doi: 10.1161/circheartfailure.109.902833</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Ammirati E, Cipriani M, Lilliu M, et al. Survival and left ventricular function changes in fulminant versus nonfulminant acute myocarditis. Circulation. 2017;136(6):529–545. doi: 10.1161/circukationaha.117.026386</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Miller DD, Holmvang G, Gill JB, et al. MRI detection of myocardial perfusion changes by gadolinium-DTPA infusion during dipyridamole hyperemia. Magn Reson Med. 1989;10(2): 246–255. doi: 10.1002/mrm.1910100209</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Paajanen H, Brasch RC, Schmiedl U, Ogan M. Magnetic resonance imaging of local soft tissue inflammation using gadolinium-DTPA. Acta Radiol. 1987;28(1):79–83.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Friedrich MG, Strohm O, Schulz-Menger J, et al. Contrast media-enhanced magnetic resonance imaging visualizes myocardial changes in the course of viral myocarditis. Circulation. 1998; 97(18):1802–1809. doi: 10.1161/01.cir.97.18.1802</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Roditi GH, Hartnell GC, Cohen MC. MRI changes in myocarditis: Evaluation with spin echo, cine MR angiography and contrast enhanced spin echo imaging. Clin Radiol. 2000;55(10):752–758. doi: 10.1053/crad.2000.0519</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Abdel-Aty H, Boye P, Zagrosek A, et al. Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: Comparison of different approaches. J Am Coll Cardiol. 2005;45(11):1815–1822. doi: 10.1016/j.jacc.2004.11.069</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Gutberlet M, Spors B, Thoma T, et al. Suspected chronic myocarditis at cardiac MR: Diagnostic accuracy and association with immunohistologically detected inflammation and viral persistence. Radiology. 2008;246(2):401–409. doi: 10.1148/radiol.2461062179</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Mahrholdt H, Goedecke C, Wagner A, et al. Cardiovascular magnetic resonance assessment of human myocarditis: A comparison to histology and molecular pathology. Circulation. 2004;109(10):1250–1258. doi: 10.1161/01.CIR.0000118493.13323.81</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Lurz P, Luecke C, Eitel I, et al. Comprehensive cardiac magnetic resonance imaging in patients with suspected myocarditis: The myoracer-trial. J Am Coll Cardiol. 2016;67(15):1800–1811. doi: 10.1016/j.jacc.2016.02.013</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Radunski UK, Lund GK, Stehning C, et al. CMR in patients with severe myocarditis: Diagnostic value of quantitative tissue markers including extracellular volume imaging. JACC Cardiovasc Imaging. 2014;7(7):667–675. doi: 10.1016/j.jcmg.2014.02.005</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Rehwald WG, Fieno DS, Chen EL, et al. Myocardial magnetic resonance imagingcontrast agent concentrations after reversible and irreversible ischemic injury. Circulation. 2002;105(2): 224–229. doi: 10.1161/hc0202.102016</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Kim RJ, Fieno DS, Parrish TB, et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation. 1999;100(19):1992–2002. doi: 10.1161/01.cir.100.19.1992</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Kim RJ, Wu E, Rafael A, et al. The Use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med. 2000;343(20):1445–1453. doi: 10.1056/NEJM200011163432003</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Abdel-Aty H, Boye P, Zagrosek A, et al. Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: Comparison of different approaches. J Am Coll Cardiol. 2005;45(11):1815–1822. doi: 10.1016/j.jacc.2004.11.069</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Laissy JP, Hyafil F, Feldman LJ, et al. Differentiating acute myocardial infarction from myocarditis: Diagnostic value of early- and delayed-perfusion cardiac MR imaging. Radiology. 2005;237(1):75–82. doi: 10.1148/radiol.2371041322</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Ferreira VM, Schulz-Menger J, Holmvang G, et al. Cardiovascular magnetic resonance in nonischemic myocardial inflammation: Expert recommendations. J Am Coll Cardiol. 2018;72(24): 3158–3176. doi: 10.1016/j.jacc.2018.09.072</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Heymans S, Eriksson U, Lehtonen J, Cooper LT. The quest for new approaches in myocarditis and inflammatory cardiomyopathy. J Am Coll Cardiol. 2016;68(21):2348–2364. doi: 10.1016/j.jacc.2016.09.937</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Ong P, Athansiadis A, Hill S, et al. Usefulness of pericardial effusion as new diagnostic criterion for noninvasive detection of myocarditis. Am J Cardiol. 2011;108(3):445–452. doi: 10.1016/j.amjcard.2011.03.068</mixed-citation></ref></ref-list></back></article>
