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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Clinical Practice</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Clinical Practice</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническая практика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2220-3095</issn><issn publication-format="electronic">2618-8627</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">18964</article-id><article-id pub-id-type="doi">10.17816/clinpract18964</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Hereditary breast cancer: present status of problem</article-title><trans-title-group xml:lang="ru"><trans-title>Наследственная форма рака молочной железы: современное состояние проблемы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gatueva</surname><given-names>F. S.</given-names></name><name xml:lang="ru"><surname>Гатуева</surname><given-names>Фатима Сослановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>врач-онколог 3-го хирургического отделения</p></bio><email>ledoffcomp@ro.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="spin">9589-9057</contrib-id><name-alternatives><name xml:lang="en"><surname>Lyubchenko</surname><given-names>L. N.</given-names></name><name xml:lang="ru"><surname>Любченко</surname><given-names>Людмила Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д.м.н., заведующая лабораторией клинической онкогенетики</p></bio><email>clingen@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="spin">7066-0295</contrib-id><name-alternatives><name xml:lang="en"><surname>Malygin</surname><given-names>S. E.</given-names></name><name xml:lang="ru"><surname>Малыгин</surname><given-names>Сергей Евгеньевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, assistant professor</p></bio><bio xml:lang="ru"><p>к.м.н., доцент кафедры онкологии и лучевой терапии</p></bio><email>drmalygin@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Oncological clinical dispensary</institution></aff><aff><institution xml:lang="ru">Республиканский онкологический диспансер</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N. N. Blokhin National Medical Research Centre of Oncology, Health Ministry of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2020-04-16" publication-format="electronic"><day>16</day><month>04</month><year>2020</year></pub-date><pub-date date-type="pub" iso-8601-date="2020-05-12" publication-format="electronic"><day>12</day><month>05</month><year>2020</year></pub-date><volume>11</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>103</fpage><lpage>111</lpage><history><date date-type="received" iso-8601-date="2019-12-26"><day>26</day><month>12</month><year>2019</year></date><date date-type="accepted" iso-8601-date="2020-03-05"><day>05</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Gatueva F.S., Lyubchenko L.N., Malygin S.E.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, Гатуева Ф.С., Любченко Л.Н., Малыгин С.Е.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Gatueva F.S., Lyubchenko L.N., Malygin S.E.</copyright-holder><copyright-holder xml:lang="ru">Гатуева Ф.С., Любченко Л.Н., Малыгин С.Е.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://clinpractice.ru/clinpractice/article/view/18964">https://clinpractice.ru/clinpractice/article/view/18964</self-uri><abstract xml:lang="en"><p>The incidence of breast cancer is increasing in most countries every year. The purpose of this literature review is to provide up-to-date information about the causes, mechanisms of development, various methods of prevention, early diagnosis and treatment of hereditary breast cancer. The effectiveness of bilateral preventive mastectomy is discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Показатели заболеваемости раком молочной железы растут в большинстве стран год от года. Цель настоящего обзора литературы — представить современные сведения о причинах, механизмах развития, различных методах профилактики, ранней диагностики и лечения наследственной формы рака молочной железы. Рассматривается эффективность двусторонней профилактической мастэктомии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hereditary breast cancer</kwd><kwd>prophylactic mastectomy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>наследственный рак молочной железы</kwd><kwd>профилактическая мастэктомия.</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Злокачественные новообразования в России в 2016 году (заболеваемость и смертность) / Под ред. Каприна А.Д., Старинского В.В., Петровой Г.В. — М.: МНИОИ им. П.А. Герцена — филиал ФГБУ «НМИРЦ» Минздрава России, 2018. — 250 с. [Zlokachestvennye novoobrazovaniya v Rossii v 2016 godu (zabolevaemost’ i smertnost’). Ed by Kaprin A.D., Starinskii V.V., Petrova G.V. Moscow: MNIOI im. P.A. Gertsena – filial FGBU «NMIRTs» Minzdrava Rossii; 2018. 250 p. 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