Journal of Clinical PracticeJournal of Clinical PracticeКлиническая практика2220-30952618-8627Eco-Vector2121810.17816/clinpract21218ReviewsНаучные обзорыReview ArticleComboridity of chronic obstructive pulmonary disease and cardiovascular diseases: general factors, pathophysiological mechanisms and clinical significanceКоморбидность хронической обструктивной болезни легких и сердечно-сосудистых заболеваний: общие факторы, патофизиологические механизмы и клиническое значениеhttps://orcid.org/0000-0002-2712-02271107-0875ChaulinA. M.ЧаулинАлексей Михайлович
Russian Federation

MD, Graduate student, Assistant of the Department

врач; аспирант

alekseymichailovich22976@gmail.comhttps://orcid.org/0000-0002-7228-10036033-0205GrigoryevaYu. V.ГригорьеваЮлия Владимировна
Russian Federation

PhD, Candidate of Medical Sciences, Associate Professor of the Department

к.м.н., доцент

histology@bk.ruhttps://orcid.org/0000-0002-6453-29765665-9578DuplyakovD. V.ДупляковДмитрий Викторович
Russian Federation

PhD, Doctor of Medical Sciences, Professor of the Department

заместитель главного врача по медицинской части; д.м.н., профессор

duplyakov@yahoo.comSamara Regional Cardiology DispensaryСамарский областной клинический кардиологический диспансерSamara State Medical UniversityСамарский государственный медицинский университет16042020120520201111121212402202016032020Copyright ©; 2020, Chaulin A.M., Grigoryeva Y.V., Duplyakov D.V.Copyright ©; 2020, Чаулин А.М., Григорьева Ю.В., Дупляков Д.В.2020Chaulin A.M., Grigoryeva Y.V., Duplyakov D.V.Чаулин А.М., Григорьева Ю.В., Дупляков Д.В.https://creativecommons.org/licenses/by-nc-nd/4.0https://clinpractice.ru/clinpractice/article/view/21218

Currently, the comorbidity (combination) of chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVD) is an important problem for the health care. This is due to the high prevalence and continuing growth of these pathologies. CVD and COPD have common risk factors and mechanisms underlying their development and progression: smoking, inflammation, sedentary lifestyle, aging, oxidative stress, air pollution, and hypoxia. In this review, we summarize the current knowledge related to the prevalence and frequency of cardiovascular diseases in people with COPD and the mechanisms that underly their coexistence. The implications for clinical practice, in particular the main problems of diagnosis and treatment of COPD/CVD comorbidity, are also discussed.

В настоящее время коморбидность (сочетание) хронической обструктивной болезни легких (ХОБЛ) и сердечно-сосудистых заболеваний (ССЗ) является актуальной проблемой для здравоохранения. Это обусловлено высокой распространенностью и продолжающимся ростом данных патологий. ССЗ и ХОБЛ имеют общие факторы риска и механизмы, лежащие в основе их развития и прогрессирования: курение, воспаление, малоподвижный образ жизни, старение, окислительный стресс, загрязнение атмосферного воздуха, гипоксия. В этом обзоре мы суммируем современные знания, касающиеся распространенности и частоты заболеваний сердечно-сосудистой системы у людей с ХОБЛ, а также механизмов, которые лежат в основе их сосуществования. Обсуждаются последствия для клинической практики, в частности основные проблемы диагностики и лечения коморбидности ХОБЛ/ССЗ.

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