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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Clinical Practice</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Clinical Practice</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническая практика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2220-3095</issn><issn publication-format="electronic">2618-8627</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">691235</article-id><article-id pub-id-type="doi">10.17816/clinpract691235</article-id><article-id pub-id-type="edn">SVEGFC</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Left ventricular summit cryoablation via the great cardiac vein in ventricular arrhythmias treatment: a case series</article-title><trans-title-group xml:lang="ru"><trans-title>Криоабляция переднебазальной части межжелудочковой перегородки через большую вену сердца для лечения желудочковых аритмий: клинические наблюдения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9247-4523</contrib-id><contrib-id contrib-id-type="spin">6338-4990</contrib-id><name-alternatives><name xml:lang="en"><surname>Khamnagadaev</surname><given-names>Igor A.</given-names></name><name xml:lang="ru"><surname>Хамнагадаев</surname><given-names>Игорь Алексеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Assistant Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, доцент</p></bio><email>i@khamnagadaev.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3366-368X</contrib-id><contrib-id contrib-id-type="spin">7650-3845</contrib-id><name-alternatives><name xml:lang="en"><surname>Tyurin</surname><given-names>Nikolay I.</given-names></name><name xml:lang="ru"><surname>Тюрин</surname><given-names>Николай Игоревич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>tyurin.nikolay@endocrincentr.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6267-3724</contrib-id><contrib-id contrib-id-type="spin">1275-2773</contrib-id><name-alternatives><name xml:lang="en"><surname>Bulavina</surname><given-names>Irina A.</given-names></name><name xml:lang="ru"><surname>Булавина</surname><given-names>Ирина Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>bulavina.irina@endocrincentr.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4917-1743</contrib-id><contrib-id contrib-id-type="spin">6468-2750</contrib-id><name-alternatives><name xml:lang="en"><surname>Belousov</surname><given-names>Leonid A.</given-names></name><name xml:lang="ru"><surname>Белоусов</surname><given-names>Леонид Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>3127325@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4169-1066</contrib-id><contrib-id contrib-id-type="spin">5527-4146</contrib-id><name-alternatives><name xml:lang="en"><surname>Ilyich</surname><given-names>Ilya L.</given-names></name><name xml:lang="ru"><surname>Ильич</surname><given-names>Илья Леонидович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>ilyich@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3394-326X</contrib-id><contrib-id contrib-id-type="spin">4738-5208</contrib-id><name-alternatives><name xml:lang="en"><surname>Garipov</surname><given-names>Rustem Sh.</given-names></name><name xml:lang="ru"><surname>Гарипов</surname><given-names>Рустэм Шамилевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>rust-garipov@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2466-7865</contrib-id><contrib-id contrib-id-type="spin">5785-5776</contrib-id><name-alternatives><name xml:lang="en"><surname>Termosesov</surname><given-names>Sergey A.</given-names></name><name xml:lang="ru"><surname>Термосесов</surname><given-names>Сергей Артурович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>stermosesov@list.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5573-0754</contrib-id><contrib-id contrib-id-type="spin">5342-7253</contrib-id><name-alternatives><name xml:lang="en"><surname>Kalashnikov</surname><given-names>Viktor Yu.</given-names></name><name xml:lang="ru"><surname>Калашников</surname><given-names>Виктор Юрьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Corresponding member of the Russian Academy of Sciences</p></bio><bio xml:lang="ru"><p>д-р мед. наук, чл.-корр. РАН</p></bio><email>Kalashnikov.Victor@endocrincentr.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5057-127X</contrib-id><contrib-id contrib-id-type="spin">7584-7015</contrib-id><name-alternatives><name xml:lang="en"><surname>Shestakova</surname><given-names>Marina V.</given-names></name><name xml:lang="ru"><surname>Шестакова</surname><given-names>Марина Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor, Academician of the Russian Academy of Sciences</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, академик РАН</p></bio><email>Shestakova.Marina@endocrincentr.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9717-9742</contrib-id><contrib-id contrib-id-type="spin">5624-3875</contrib-id><name-alternatives><name xml:lang="en"><surname>Mokrysheva</surname><given-names>Natalia G.</given-names></name><name xml:lang="ru"><surname>Мокрышева</surname><given-names>Наталья Георгиевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor, Academician of the Russian Academy of Sciences</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, академик РАН</p></bio><email>mokrisheva.natalia@endocrincentr.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Endocrinology Research Centre</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр эндокринологии имени академика И.И. Дедова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">The Russian National Research Medical University named after N.I. Pirogov</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Buyanov City Clinical Hospital</institution></aff><aff><institution xml:lang="ru">Городская клиническая больница им. В.М. Буянова</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2026-05-31" publication-format="electronic"><day>31</day><month>05</month><year>2026</year></pub-date><pub-date date-type="pub" iso-8601-date="2026-08-06" publication-format="electronic"><day>06</day><month>08</month><year>2026</year></pub-date><volume>17</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>179</fpage><lpage>186</lpage><history><date date-type="received" iso-8601-date="2025-09-23"><day>23</day><month>09</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2026-02-24"><day>24</day><month>02</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Эко-Вектор</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://clinpractice.ru/clinpractice/article/view/691235">https://clinpractice.ru/clinpractice/article/view/691235</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND:</bold> The presented clinical cases demonstrate that cryoablation via the great cardiac vein can be an effective radical surgical treatment in ventricular arrhythmias originating in the left ventricular summit. Conventional transcatheter radiofrequency ablation may be contraindicated if the ablation area is close to the coronary arteries. <bold>CLINICAL CASE DESCRIPTIONS:</bold> We present two clinical cases where cryoablation was used for the treatment of life-threatening ventricular arrhythmias. Conventional transcatheter radiofrequency ablation was not possible in both cases because the left main coronary artery was close to the ablation area (less than 5 mm). This necessitated mapping of the right and left ventricles, sinuses of Valsalva, coronary sinus, and great cardiac vein. Epicardial arrhythmogenic substrate was detected. A cryocatheter was inserted in the earliest ventricular activation zone with ectopic activity, followed by successful cryoablation of the arrhythmic focus. <bold>CONCLUSION:</bold> When the ventricular arrhythmia substrate is localized in the left ventricular summit, the epicardial approach via the great cardiac vein is an optimal access route for interventional treatment. Catheter ablation in this area requires consideration of the coronary artery topology. If the arrhythmogenic substrate is close to the coronary vessels, cryoablation may be the best option, providing an effective and safe intervention.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Клинические случаи иллюстрируют возможность успешного радикального хирургического лечения желудочковых аритмий с локализацией аритмогенного субстрата в переднебазальной области выводного тракта левого желудочка при помощи криоабляции через большую вену сердца. Стандартный подход в лечении данного нарушения ритма сердца связан с использованием транскатетерной радиочастотной абляции, однако метод неприменим при близком расположении коронарных артерий к области воздействия. <bold>Описание клинических случаев.</bold> Приводим два клинических наблюдения, в которых для лечения жизнеугрожающих желудочковых нарушений ритма сердца применялась технология криоабляции. Традиционный подход (транскатетерная радиочастотная абляция) в обоих случаях был невозможен из-за близкого расположения (менее 5 мм) ствола левой коронарной артерии от зоны воздействия, в связи с чем выполнено картирование правого и левого желудочка, синусов Вальсальвы, коронарного синуса и большой вены сердца. Выявлена эпикардиальная локализация аритмогенного субстрата. Криокатетер позиционирован в зоне наиболее ранней активации желудочков на фоне эктопической активности с последующим успешным выполнением криоабляции фокуса аритмии. <bold>Заключение.</bold> При локализации субстрата желудочковой экстрасистолии в переднебазальной части межжелудочковой перегородки одним из оптимальных для интервенционного лечения является эпикардиальный доступ, который может быть выполнен через большую вену сердца. При выполнении катетерной абляции в данной области следует учитывать топографию коронарных артерий. В случае локализации аритмогенного субстрата в непосредственной близости от коронарного русла криоабляция может рассматриваться как оптимальная технология, обеспечивающая эффективность и безопасность вмешательства.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ventricular extrasystole</kwd><kwd>cryoablation</kwd><kwd>radiofrequency ablation</kwd><kwd>coronary sinus</kwd><kwd>clinical case</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>желудочковая экстрасистолия</kwd><kwd>криоабляция</kwd><kwd>радиочастотная абляция</kwd><kwd>коронарный синус</kwd><kwd>клинический случай</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="en">Ministry of Health of the Russian Federation</institution></institution-wrap><institution-wrap><institution xml:lang="ru">Министерство здравоохранения Российской Федерации</institution></institution-wrap></funding-source><award-id>056-00045-23-00</award-id></award-group><funding-statement xml:lang="en">State assignment Research project No. 123021000043-0, 2023-2025.</funding-statement><funding-statement xml:lang="ru">Государственное задание НИР № 123021000043-0, 2023–2025 гг.</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Dukes JW, Dewland TA, Vittinghoff E, et al. 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