Journal of Clinical PracticeJournal of Clinical PracticeКлиническая практика2220-30952618-8627Eco-Vector69628810.17816/clinpract696288UYTUDJReviewsНаучные обзорыReview ArticleAssociation between prediabetes and sarcopenia risk: a systematic review and meta-analysisСвязь между предиабетом и риском саркопении: систематический обзор и метаанализhttps://orcid.org/0000-0001-7875-6973NugrohoH.НугрохоХ.
Indonesia

MD; Division of Diabetes, Endocrine, and Metabolism, Department of Internal Medicine, Faculty of Medicine

доктор медицины; Отделение диабета, эндокринологии и метаболизма, кафедра внутренних болезней, медицинский факультет

khris_heri@yahoo.comhttps://orcid.org/0000-0003-1783-8531AlviantoS.АльвиантоС.
Indonesia

MD; School of Medicine and Health Sciences

доктор медицины; Школа медицины и наук о здоровье

alvianto_steven@yahoo.comhttps://orcid.org/0000-0003-4616-5671PratamaK.ПратамаК.
Indonesia

MD; Department of Internal Medicine, Faculty of Medicine

доктор медицины; Кафедра внутренних болезней, медицинский факультет

kevingracia14@gmail.comDiponegoro UniversityУниверситет ДипонегороAtma Jaya Catholic University of IndonesiaКатолический университет Атма-Джая150720260608202617269801511202526112025Copyright ©; 2026, Eco-VectorCopyright ©; 2026, Эко-Вектор2026Eco-VectorЭко-Векторhttps://creativecommons.org/licenses/by-nc-nd/4.0https://clinpractice.ru/clinpractice/article/view/696288

BACKGROUND: Sarcopenia, the loss of muscle mass and strength, is a growing concern, especially in aging populations. Prediabetes, an intermediate state between normal glucose levels and diabetes, has been increasingly linked to muscle decline. AIM: to examine the association between prediabetes and sarcopenia risk. METHODS: A systematic search was conducted across databases including PubMed, ProQuest, Science Direct, Google Scholar, and the Cochrane Library to identify relevant studies on prediabetes and sarcopenia risk. Study quality was evaluated using the Newcastle-Ottawa Scale, and a meta-analysis was performed using Review Manager version 5.4. RESULTS: Five observational studies were included, with four undergoing quantitative synthesis. Results showed that individuals with prediabetes had a significantly higher likelihood of developing sarcopenia compared to those with normal glucose regulation (pooled OR 1.29, 95% CI 1.13–1.47; I2 = 7%). CONCLUSION: Prediabetes was associated with increased odds of sarcopenia. However, these findings should be interpreted with caution due to the small number of studies. Despite these limitations, the results highlight the importance of early detection and management of prediabetes to reduce the risk of sarcopenia.

Обоснование. Саркопения — заболевание связанное с потерей мышечной массы и слабостью — вызывает растущую озабоченность в связи со старением населения. Предиабет, промежуточное состояние между нормальным уровнем глюкозы и диабетом, всё чаще связывают с дисфункцией мышц. Цель данного исследования — изучить связь между предиабетом и риском развития саркопении. Методы. Проведён систематический поиск по базам данных, включая PubMed, ProQuest, ScienceDirect, Google Scholar и Cochrane Library, с целью выявления релевантных исследований, посвящённых предиабету и риску саркопении. Качество исследований оценивалось с помощью шкалы Ньюкасла–Оттавы, а метаанализ проводился с использованием программы Review Manager версии 5.4. Результаты. В анализ включено пять обсервационных исследований, четыре из которых прошли количественный синтез (всего проанализировано 30 511 человек с нормальным метаболизмом глюкозы и 13 861 человек с предиабетом). Результаты показали, что у лиц с предиабетом вероятность развития саркопении была значительно выше по сравнению с лицами с нормальным уровнем глюкозы (объединённое ОШ 1,29, 95% ДИ 1,13–1,47; I2 = 7%). Заключение. Предиабет связан с повышенным риском развития саркопении. Даже с учётом ограничений проведённого метаанализа по количеству включённых исследований полученные результаты подчёркивают важность раннего выявления и лечения предиабета для снижения риска развития саркопении.

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