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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Clinical Practice</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Clinical Practice</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническая практика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2220-3095</issn><issn publication-format="electronic">2618-8627</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">696935</article-id><article-id pub-id-type="doi">10.17816/clinpract696935</article-id><article-id pub-id-type="edn">CYHEYL</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Arthrogenic muscle inhibition аfter anterior cruciate ligament rupture: a systematic review</article-title><trans-title-group xml:lang="ru"><trans-title>Артрогенное мышечное ингибирование после разрыва передней крестообразной связки. Систематический обзор</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2794-4912</contrib-id><contrib-id contrib-id-type="spin">6274-4448</contrib-id><name-alternatives><name xml:lang="en"><surname>Skvortsov</surname><given-names>Dmitry V.</given-names></name><name xml:lang="ru"><surname>Скворцов</surname><given-names>Дмитрий Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>dskvorts63@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-3689-7417</contrib-id><name-alternatives><name xml:lang="en"><surname>Gulyakovich</surname><given-names>Alexey I.</given-names></name><name xml:lang="ru"><surname>Гулякович</surname><given-names>Алексей Игоревич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>gulyakovich@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2938-5173</contrib-id><contrib-id contrib-id-type="spin">9965-1828</contrib-id><name-alternatives><name xml:lang="en"><surname>Akhpashev</surname><given-names>Alexander A.</given-names></name><name xml:lang="ru"><surname>Ахпашев</surname><given-names>Александр Анатольевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>akhpashev@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies</institution></aff><aff><institution xml:lang="ru">Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">The Russian National Research Medical University named after N.I. Pirogov</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Family Clinic ZIM</institution></aff><aff><institution xml:lang="ru">Семейная Клиника «ЗИМ»</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов имени Патриса Лумумбы</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2026-06-08" publication-format="electronic"><day>08</day><month>06</month><year>2026</year></pub-date><pub-date date-type="pub" iso-8601-date="2026-08-06" publication-format="electronic"><day>06</day><month>08</month><year>2026</year></pub-date><volume>17</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>125</fpage><lpage>138</lpage><history><date date-type="received" iso-8601-date="2025-11-24"><day>24</day><month>11</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2026-02-14"><day>14</day><month>02</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Эко-Вектор</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://clinpractice.ru/clinpractice/article/view/696935">https://clinpractice.ru/clinpractice/article/view/696935</self-uri><abstract xml:lang="en"><p>Arthrogenic muscle inhibition is a major concern in modern sports traumatology and orthopedic surgery, considerably limiting functional recovery following anterior cruciate ligament reconstruction. Despite advancements in surgical techniques and rehabilitation programs, approximately half of patients do not achieve complete recovery and experience recurrent episodes of muscle weakness with reduced quadriceps strength and knee joint stability. The work aimed to provide a comprehensive review of existing research on neurophysiological mechanisms, clinical manifestations, and potential therapeutic interventions for arthrogenic muscle inhibition following anterior cruciate ligament reconstruction. A search of studies published between 2000 and 2024 was performed in PubMed, EMBASE, CINAHL, Cochrane Library, and Google Scholar. The search terms included arthrogenic muscle inhibition, anterior cruciate ligament reconstruction, quadriceps activation, and rehabilitation strategies. The final analysis included randomized controlled and observational studies that met strict inclusion criteria; single-arm studies, case reports, and animal experiments were excluded. An analysis of 70 publications found that arthrogenic muscle inhibition is reported in 43% of patients after anterior cruciate ligament reconstruction. It is associated with both impaired quadriceps activation and considerable alterations in spinal and supraspinal neurophysiological structures. Cryotherapy, neuromuscular electrical stimulation, and structured exercise programs demonstrated are moderately effective in reducing arthrogenic muscle inhibition in both the early and late postoperative periods. Transcranial magnetic stimulation is a promising therapeutic option. Following anterior cruciate ligament injury, early diagnosis of arthrogenic muscle inhibition and the determination of an adequate treatment strategy are essential. This improves reconstruction success rates and functional outcomes while reducing the long-term risk of recurrent injuries.</p></abstract><trans-abstract xml:lang="ru"><p>Артрогенное мышечное ингибирование представляет серьёзную проблему современной спортивной травматологии и ортопедии, существенно ограничивающей функциональное восстановление пациентов после пластики передней крестообразной связки. Несмотря на прогресс в хирургических техниках и развитии реабилитационных программ, до половины пациентов не достигают полного восстановления и сталкиваются с рецидивирующими эпизодами мышечной слабости, снижением силы и устойчивости коленного сустава. В исследовании выполнен всесторонний анализ актуальных научных данных по вопросам нейрофизиологических механизмов, клинических проявлений и возможных терапевтических вмешательств при артрогенном мышечном ингибировании, возникающем после реконструкции передней крестообразной связки, для чего проведён поиск источников по базам данных PubMed, EMBASE, CINAHL, Cochrane Library и Google Scholar за период 2000–2024 годов с использованием поисковых ключевых слов, связанных с артрогенным мышечным ингибированием, реконструкцией передней крестообразной связки, активацией квадрицепса и мерами реабилитации. В итоговый анализ включены рандомизированные контролируемые и наблюдательные исследования. Анализ 70 работ показал, что артрогенное мышечное ингибирование развивается у 43% пациентов после пластики передней крестообразной связки и ассоциируется как с нарушением активации четырёхглавой мышцы, так и со значительными изменениями в спинальных и супраспинальных нейрофизиологических структурах. Умеренную эффективность снижения проявлений артрогенного мышечного ингибирования в раннем и позднем постоперационном периоде демонстрируют криотерапия, нейромышечная электростимуляция, структурированные комплексы упражнений; перспективным направлением остаётся транскраниальная магнитная стимуляция. При повреждении передней крестообразной связки необходимо в ранние сроки провести диагностику синдрома артрогенного мышечного ингибирования и определить необходимое лечение: это позволяет повысить успех реконструкции, улучшить функциональные исходы и снизить частоту повторных травм в долгосрочной перспективе.</p></trans-abstract><kwd-group xml:lang="en"><kwd>muscle strength</kwd><kwd>anterior cruciate ligament injuries</kwd><kwd>muscle weakness</kwd><kwd>quadriceps femoris muscle</kwd><kwd>rehabilitation</kwd><kwd>anterior cruciate ligament reconstruction</kwd><kwd>physical therapy</kwd><kwd>neuromuscular blockade</kwd><kwd>cryotherapy</kwd><kwd>review</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>мышечная сила</kwd><kwd>травмы передней крестообразной связки</kwd><kwd>мышечная слабость</kwd><kwd>четырёхглавая мышца бедра</kwd><kwd>реабилитация</kwd><kwd>восстановление передней крестообразной связки</kwd><kwd>физиотерапевтические методы</kwd><kwd>нервно-мышечная блокада</kwd><kwd>криотерапия</kwd><kwd>обзор</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="en">Federal Medical-Biological Agency of Russia</institution></institution-wrap><institution-wrap><institution xml:lang="ru">ФМБА России</institution></institution-wrap></funding-source></award-group><funding-statement xml:lang="en">The study was conducted as part of a state assignment by the Federal Medical-Biological Agency of Russia.</funding-statement><funding-statement xml:lang="ru">Исследование выполнено в рамках государственного задания ФМБА России.</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Harkey MS, Gribble PA, Pietrosimone BG. 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