Journal of Clinical PracticeJournal of Clinical PracticeКлиническая практика2220-30952618-8627Eco-Vector7087310.17816/clinpract70873ReviewsНаучные обзорыReview ArticleRegenerative rehabilitation of skeletal muscle damagesРегенеративная реабилитация повреждений скелетных мышцhttps://orcid.org/0000-0001-5047-27921537-9822SсherbakSergey G.ЩербакСергей Григорьевич
Russian Federation

M.D., Ph.D., Dr. Sci. (Med.), Professor

д.м.н., профессор

b40@zdrav.spb.ruhttps://orcid.org/0000-0002-1595-66688114-3984MakarenkoStanislav V.МакаренкоСтанислав Вячеславович
Russian Federation

Assistant Lecturer

ассистент кафедры

st.makarenko@gmail.comhttps://orcid.org/0000-0001-6360-132X2922-4404KamilovaTatyana A.КамиловаТатьяна Аскаровна
Russian Federation

Ph.D.

к.б.н.

kamilovaspb@mail.ruhttps://orcid.org/0000-0002-5632-39637234-7870GolotaAlexander S.ГолотаАлександр Сергеевич
Russian Federation

M.D., Ph.D., Associate Professor

к.м.н., доцент

golotaa@yahoo.comhttps://orcid.org/0000-0003-3198-89907922-2751SaranaAndrey M.СаранаАндрей Михайлович
Russian Federation

M.D., Ph.D.

к.м.н.

asarana@mail.ruSaint-Petersburg State UniversityСанкт-Петербургский государственный университетSaint-Petersburg City Hospital No 40 of Kurortny DistrictГородская больница № 40 Курортного административного районаSaint-Petersburg State UniversityСанкт-Петербургский государственный университетHealth Committee of Saint PetersburgКомитет по здравоохранению Администрации Санкт-Петербурга0406202115122021124Клиническая практика51652005202102062021Copyright ©; 2021, Sсherbak S.G., Makarenko S.V., Kamilova T.A., Golota A.S., Sarana A.M.Copyright ©; 2021, Щербак С.Г., Макаренко С.В., Камилова Т.А., Голота А.С., Сарана А.М.2021Sсherbak S.G., Makarenko S.V., Kamilova T.A., Golota A.S., Sarana A.M.Щербак С.Г., Макаренко С.В., Камилова Т.А., Голота А.С., Сарана А.М.https://creativecommons.org/licenses/by-nc-nd/4.0https://clinpractice.ru/clinpractice/article/view/70873

The article is devoted to the analysis of the current state of regenerative and rehabilitative treatments of skeletal muscles, the possibilities of restoring the functioning of tissue lost due to aging, injuries or diseases. The study of the molecular genetic basis of mechanotransduction and mechanotherapy will allow the identification of genes and molecules, the expression levels of which can serve as biomarkers of the effectiveness of regenerative-rehabilitation measures. These mechanisms are potential therapeutic targets for stimulating of regeneration of skeletal muscles. The focus of the article is on the choice of an individual approach, both when conducting basic scientific research and developing rehabilitation programs. All this will significantly improve patient outcomes.

Статья посвящена анализу современного состояния регенеративно-реабилитационного лечения повреждений скелетных мышц, возможностям восстановления функций мышечной ткани, утраченных в результате старения, травм или болезней. Изучение молекулярно-генетических основ механотрансдукции и механотерапии позволит идентифицировать гены и молекулы, уровни экспрессии которых могут служить биомаркерами эффективности регенеративно-реабилитационных мероприятий. Эти механизмы представляют собой потенциальные терапевтические мишени для стимуляции регенерации скелетных мышц. Основное внимание в статье обращается на выбор индивидуального подхода как при проведении фундаментальных научных исследований, так и при разработке программ реабилитации. Все это позволит значительно улучшить результаты лечения пациентов.

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