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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Clinical Practice</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Clinical Practice</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническая практика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2220-3095</issn><issn publication-format="electronic">2618-8627</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">8258</article-id><article-id pub-id-type="doi">10.17816/clinpract4256-67</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">OBTAINING AND APPLICATION PERSPECTIVESOF GENETICALLY MODIFIED PLURIPOTENT STEM CELLS</article-title><trans-title-group xml:lang="ru"><trans-title>ПОЛУЧЕНИЕ И ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ ГЕНЕТИЧЕСКИ МОДИФИЦИРОВАННЫХ ПЛЮРИПОТЕНТНЫХ СТВОЛОВЫХ КЛЕТОК</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kazachenko</surname><given-names>K Yu</given-names></name><name xml:lang="ru"><surname>Казаченко</surname><given-names>Константин Юрьевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший научный сотрудник лаборатории генетики Центра клеточных технологий ФГБУ ФНКЦ ФМБА России, к.б.н.</p></bio><email>infirmus100@yahoo.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГБУ ФНКЦ ФМБА России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2013</year></pub-date><volume>4</volume><issue>2</issue><issue-title xml:lang="en">NO2 (2013)</issue-title><issue-title xml:lang="ru">№2 (2013)</issue-title><fpage>56</fpage><lpage>67</lpage><history><date date-type="received" iso-8601-date="2018-03-16"><day>16</day><month>03</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Kazachenko K.Y.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, Казаченко К.Ю.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Kazachenko K.Y.</copyright-holder><copyright-holder xml:lang="ru">Казаченко К.Ю.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://clinpractice.ru/clinpractice/article/view/8258">https://clinpractice.ru/clinpractice/article/view/8258</self-uri><abstract xml:lang="en"><p>This review considers genetic modelling of pluripotent stem cells, the problems of experimental studies and prospects of practical application.</p></abstract><trans-abstract xml:lang="ru"><p>В данном обзоре рассмотрены способы генетического моделирования плюрипотентных стволовых клеток, проблемы экспериментальных исследований данного направления и перспективы практического применения.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>стволовые клетки</kwd><kwd>плюрипотентность</kwd><kwd>дифференцировка</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Lavker R.M., Sun T.T. 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