Journal of Clinical PracticeJournal of Clinical PracticeКлиническая практика2220-30952618-8627Eco-Vector834010.17816/clinpract6348-58ArticlesСтатьиResearch ArticleCELL THERAPY OF STROKE AND SPINAL CORD INJURY COMPLICATIONSКЛЕТОЧНАЯ ТЕРАПИЯ ОСЛОЖНЕНИЙ ИНСУЛЬТА И ПОЗВОНОЧНО-СПИННОМОЗГОВОЙ ТРАВМЫKonoplyannikovM AКоноплянниковМихаил Анатольевич

зав. лабораторией клеточных технологий ФНКЦ ФМБА России

mkonopl@mail.ruBaklaushevV PБаклаушевВладимир Павлович

д.м.н., заместитель генерального директора по научной работе и медицинским технологиям ФГБУ ФНКЦ ФМБА России; доцент кафедры медицинских нанобиотехнологий МБФ РНИМУ им. Н.И. Пирогова

serpoff@mail.ruKalsinV AКальсинВладимир Анатольевич

научный сотрудник лаборатории клеточных технологий ФНКЦ ФМБА России

TikhonovskyM AТихоновскийМихаил Андреевич

научный сотрудник группы нейрореабилитации отдела реабилитации и спортивной травмы ФНКЦ ФМБА России

AveryanovA VАверьяновАлександр Вячеславович

зав. отделением пульмонологии ФНКЦ ФМБА России, Руководитель Центра биомедицинских технологий ФНКЦ ФМБА России

averyanovav@mail.ruФНКЦ ФМБА России1509201563NO3 (2015)№3 (2015)485816032018Copyright ©; 2015, Konoplyannikov M.A., Baklaushev V.P., Kalsin V.A., Tikhonovsky M.A., Averyanov A.V.Copyright ©; 2015, Коноплянников М.А., Баклаушев В.П., Кальсин В.А., Тихоновский М.А., Аверьянов А.В.2015Konoplyannikov M.A., Baklaushev V.P., Kalsin V.A., Tikhonovsky M.A., Averyanov A.V.Коноплянников М.А., Баклаушев В.П., Кальсин В.А., Тихоновский М.А., Аверьянов А.В.https://creativecommons.org/licenses/by-nc-nd/4.0https://clinpractice.ru/clinpractice/article/view/8340

The review analyzes the current advances of cell therapy for neurological complications of ischemic stroke and spinal cord injury (SCI). We demonstrate the most recent data on the use of different types of stem cells for the treatment of these severe damages, obtained both in experimental studies using animal models and in clinical studies. We particularly discuss the use of mesenchymal stem cells (MSC) and neural stem/progenitor cells (NSC/NPC) for the treatment of stroke and SCI. We also discuss the prospects for a further development of cell therapy of these diseases.

В обзоре анализируется современное состояние проблемы клеточной терапии неврологических осложнений ишемического инсульта и позвоночно-спинномозговой травмы (ПСМТ). Приводятся современные данные по использованию различных типов стволовых клеток для терапии данных тяжелых нарушений, полученные как в экспериментальных исследованиях на животных моделях, так и в результате клинических исследований. Наиболее подробно рассматривается применение мезенхимальных стволовых клеток (МСК) и нейральных стволовых/ прогениторных клеток (НСК/НПК) для терапии инсульта и ПСМТ. Обсуждаются дальнейшие перспективы развития клеточной терапии указанных заболеваний.

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