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Synthesis and study of antibacterial and anti-mao activity of new pyrazoline and pyrimidine derivatives based on (e)-1-(4-amyloxyphenyl)-3-arylprop-2-en-1-ones
- Authors: Isakhanyan A.U.1, Hovasyan Z.A.1, Madoyan R.A.2, Sukiasyan A.G.2, Chailyan S.G.2, Grigoryan A.S.1, Gasparyan H.V.1, Harutyunyan A.A.1
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Affiliations:
- Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- Institute of Biochemistry named after G. Buniatyan of the National Academy of Sciences of the Republic of Armenia
- Issue: Vol 51, No 1 (2025)
- Pages: 137-143
- Section: Articles
- URL: https://clinpractice.ru/0132-3423/article/view/683103
- DOI: https://doi.org/10.31857/S0132342325010126
- EDN: https://elibrary.ru/LYSDQL
- ID: 683103
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Abstract
Five chalcones from the pentyloxyacetophenone series with aromatic aldehydes have been synthesized. New pyrazoline and pyrimidine derivatives have been successfully synthesized on their basis The antimicrobial activity of 15 synthesized compounds was studied. Antimicrobial and antifungal activity was determined by the agar diffusion method. Studies have shown that out of 15 compounds, 9 exhibit high antifungal activity against pathogenic fungi of the genus Candida, and some compounds exhibit antagonistic activity against pathogenic strains of Escherichia coli and Staphylococcus aureus. Studies of anti-monoamine oxidase activity showed that two compounds showed moderate activity at a concentration of 1.0 mM, inhibiting the deamination of 5-oxytryptamine (serotonin) by 68 and 65%, respectively, and the remaining compounds showed weak anti-MAO activity.
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About the authors
A. U. Isakhanyan
Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Author for correspondence.
Email: anush.isakhanyan.51@mail.ru
Armenia, Azatutyana
Z. A. Hovasyan
Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
Armenia, Yerevan
R. A. Madoyan
Institute of Biochemistry named after G. Buniatyan of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
Armenia, Yerevan
A. G. Sukiasyan
Institute of Biochemistry named after G. Buniatyan of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
Armenia, Yerevan
S. G. Chailyan
Institute of Biochemistry named after G. Buniatyan of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
Russian Federation, Yerevan
A. S. Grigoryan
Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
Armenia, Yerevan
H. V. Gasparyan
Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
Russian Federation, Yerevan
A. A. Harutyunyan
Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
Armenia, Yerevan
References
- Shivananda M.K., Holla B.S. // J. Chem. Pharm. Res. 2017. V. 9. № 6. P. 1.
- Khan S.A., Asiri A.M., Al-Ghamdi N.S.M., Asad M., Zayed M.E.M., Elroby S.A.K., Aqlan F.M., Wani M.Y., Sharma K. // J. Mol. Struct. 2019. V. 1190. P. 77. https://doi.org/10.1016/j.molstruc.2019.04.046
- Gouhar R.S. // J. Heterocycl. Chem. 2018. V. 55. P. 2368. https://doi.org/10.1002/jhet.3301
- Rammohan A., Reddy J.S., Sravya G., Rao C.N., Zyryanov G.V. // Environ. Chem. Lett. 2020. V. 18. P. 433. https://doi.org/10.1007/s10311-019-00959-w
- Elkanzi N.A.A. // Orient. J. Chem. 2020. V. 36. P. 1001. https://doi.org/10.13005/ojc/360602
- Ahmed M.H., El-Hashash M.A., Marzouk M.I., ElNaggar A.M. // J. Heterocycl. Chem. 2019. V. 56. P. 114. https://doi.org/10.1002/jhet.3380
- Chinh L.V., Hung T.N., Nga N.T., Hang T.T.N., Mai T.T.N. Tarasevich V.A. // Russ. J. Org. Chem. 2014. V. 50. P. 1767. https://doi.org/10.1134/S1070428014120094
- Varghese B., Al-Busafi S.N., Suliman F.O., AlKindy S.M.Z. // RSC Adv. 2017. V. 7. P. 46999. https://doi.org/10.1039/C7RA08939B
- Chu W.-C., Bai P.-Y., Yang J.-Q., Cui D.-Y., Hua Y.-G., Yang Y., Yang Q.-Q., Zhang E. Qin S. // Eur. J. Med. Chem. 2018. V. 143. P. 905. https://doi.org/10.1016/j.ejmech.2017.12.009
- Yadav P., Lal K., Kumar L., Kumar A., Kumar A., Paul A.K., Kumar R. // Eur. J. Med. Chem. 2018. V. 155. P. 263. https://doi.org/10.1016/j.ejmech.2018.05.055
- Rani A., Anand A., Kumar K., Kumar V. // Exp. Opin. Drug Discov. 2019. V. 14. P. 249–288. https://doi.org/10.1080/17460441.2019.1573812
- Alam J., Alam O., Shrivastava N., Naim M., Alam P. // Int. J. Pharmacol. Pharm. Sci. 2015. V. 2. P. 55.
- Общая и санитарная микробиология с техникой микробиологических исследований: учебное пособие / Под ред. Лабинской А.С., Блинковой Л.П., Ещиной А.С. Москва: Медицина, 2004, С. 189
- Руководство к практическим занятиям по микробиологии / Под. ред. Егорова Н.С. Изд-во МГУ, 1995. С. 224.
- Patil S.B. // Int. J. Pharm. Sci. Res. 2024. V. 15. P. 2943– 2962.
- Руководство к практическим занятиям по микробиологии / Под. ред. Егорова Н.С. Изд-во МГУ, 1995. С. 224.
- Pfaller M.A., Diekema D.J., Rinaldi M.G., Barnes R., Hu B., Veselov A.V., Tiraboschi N., Nagy E., Gibbs D.L. // J. Clin. Microbiol. 2005. V. 43. Р. 5848.
- Pfaller M.A., Diekema D.J. // Clin. Microbiol. Rev. 2007. V. 20. P. 133.
- Kaur J., Nobile C.J. // Curr. Opin. Microbiol. 2023. V. 71. P. 102237.
- Siddiqui A.A., Rajesh R., Mojahid-Ul-Islam, Alagarsamy V., De Clercq E. // Archiv der Pharmazie. 2007. V. 340. P. 95. https://doi.org/10.1002/ardp.200600121
- Горькин В.З. // Методы, основанные на измерении освобождаемого аммиака. 1981. М, с. 34.
- Машковский М. Д. // Индопан. Лекарственные средства. М.: Новая волна, 2010. С. 851.
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