Synthesis and Antioxidant Activity (4-(Benzo[d][1,3]-dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylsubstituted Aryloxypropanolamines, Aminoamides and Sulfanilamides
- Autores: Arustamyan Z.S.1, Margaryan R.E.1, Mkryan G.G.1, Aghekyan A.A.1, Panosyan G.A.1, Buniatyan Z.M.1, Muradyan R.E.1
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Afiliações:
- The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
- Edição: Volume 60, Nº 1 (2024)
- Páginas: 86-93
- Seção: Articles
- URL: https://clinpractice.ru/0514-7492/article/view/672237
- DOI: https://doi.org/10.31857/S0514749224010072
- EDN: https://elibrary.ru/ENFSQA
- ID: 672237
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Resumo
Alkylation of 3,4-methylenedioxyphenylacetоnitrile with 2,2-dichlorodiethyl ether gave the corresponding nitrile the reduction of which with lithium aluminum hydride isolated (4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamine. The interaction of the latter with aryloxymethyloxiranes gave the corresponding 1-((4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamino)-3-aryloxypropan-2-ols. By the reaction of the same amine with chloroacetyl chloride isolated chloroacetamide, the interaction of which with a variety of secondary amines and heterylthiols synthesized the corresponding substituted amino- and sulfanylacetamides - derivatives of (4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamine. The antioxidant activity of the obtained compounds was studied.
Texto integral

Sobre autores
Zh. Arustamyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Autor responsável pela correspondência
Email: aaghekyan@mail.ru
ORCID ID: 0000-0002-0541-5315
Armênia, Yerevan
R. Margaryan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID ID: 0000-0002-5066-0870
Armênia, Yerevan
G. Mkryan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID ID: 0000-0001-9879-9524
Armênia, Yerevan
A. Aghekyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID ID: 0000-0001-6151-4951
Armênia, Yerevan
G. Panosyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
Armênia, Yerevan
Zh. Buniatyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID ID: 0000-0001-8311-6276
Armênia, Yerevan
R. Muradyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID ID: 0000-0002-4110-9454
Armênia, Yerevan
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