A STUDY OF ATROPINE INFLUENCE ON ACHE AND BCHE GENES EXPRESSION IN RATS EXPOSED TO MALATHION POISONING

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Abstract

Levels of expression of Ache and Bche genes in tissue samples were investigated in rats exposed to malathion in dose of 1 LD50 and following atropine treatment. Malathion poisoning causes statistically significant decrease in levels of expression of Ache and Bche genes in brain and liver. The decrease of expression of these genes was greater than 50% and remained at this level during 14 days. It was shown that atropine treatment prevents decrease in Ache gene expression in brain. These findings suggest the possibility of gene expression level assessment in brain during the screening of promising treatments for OP poisoning.

About the authors

Aleksandr Vladimirovich Babkin

Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)

Author for correspondence.
Email: noemail@neicon.ru

Научный сотрудник НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург, Российская Федерация

e-mail: babkinnik@yandex.ru

Russian Federation

Irina Sergeevna Berdinskih

Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)

Email: noemail@neicon.ru

Научный сотрудник НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург, Российская Федерация

e-mail: irina_berdinskih@mail.ru

Russian Federation

Natalya Sergeevna Osechkina

Federal State Scientific Institution «Institute of Toxicology» Federal Medico-Biological Agency of Russia

Email: noemail@neicon.ru

Научный сотрудник ФГУН «Институт Токсикологии» ФМБА России, 192019, г. Санкт-Петербург, Российская Федерация

e-mail: dunats@rambler.ru

Russian Federation

Georgiy Valerevich Nazarov

Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)

Email: noemail@neicon.ru

Доктор химических наук, доцент, начальник отдела НИИИ ВМ ВМедА им. С.М. Кирова Министерства обороны Российской Федерации, 195043, г. Санкт-Петербург, Российская Федерация

e-mail: denis-100@list.ru

Russian Federation

Mikhail Anatol’evich Yudin

Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)

Email: noemail@neicon.ru

Кандидат медицинских наук, доцент, заместитель начальника отдела НИИИ (ВМ) ВМедА им. С.М. Кирова, 195043, г. Санкт-Петербург, Российская Федерация

e-mail: mikhail.judin@gmail.com

Russian Federation

Vladimir Nikolaevich Bykov

Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)

Email: noemail@neicon.ru

Доктор медицинских наук, профессор, начальник НИИЦ (МБЗ) НИИИ (ВМ) ВМедА им. С.М. Кирова, 195043, г. Санкт-Петербург, Российская Федерация

e-mail: bykov_imm@yahoo.com

Russian Federation

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Copyright (c) 2015 Babkin A.V., Berdinskih I.S., Osechkina N.S., Nazarov G.V., Yudin M.A., Bykov V.N.


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