Email this article Study of the toxicity of combustion products of polymer materials using chromatomass spectrometry
- Authors: Shishonok M.F.1, Karmanov E.Y.1, Ukolov A.I.1, Zemlyanoi A.V.1, Yerunova N.V.1, Nikolaev A.I.1, Borodavko V.K.1, Dulov S.A.1, Radilov A.S.1
-
Affiliations:
- Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
- Issue: No 3 (2022)
- Pages: 167-176
- Section: Original articles
- Published: 20.06.2022
- URL: https://clinpractice.ru/0869-7922/article/view/641420
- DOI: https://doi.org/10.47470/0869-7922-2022-30-3-167-176
- ID: 641420
Cite item
Full Text
Abstract
Introduction. Carrying out studies of the toxicity of combustion products (HCL50) of polymer materials: epoxy glue grade EK-5T and compound ELPLAST-180ID according to GOST with the additional use of gas chromatography with mass selective detection.
Objective. Experimental study of the toxicity of combustion products (HCL50) of polymer materials in various modes of thermal oxidative degradation: epoxy glue grade EK-5T and compound ELPLAST-180ID, as well as a survey mass spectrometric analysis of products of thermal oxidative degradation.
Material and methods. The studies were carried out in accordance with GOST 12.1.044-89. Equipment: “Toxicity” unit, “Infracar M2.01” gas analyzer, Focus GC chromato-mass-spectrometric instrumental complex with DSQ II mass spectrometer (Thermo Scientific, USA), Nova Medical Stat Profile automatic analyzer of blood gases, electrolytes and oximetry Model CCX (USA). Blood sampling was carried out in capillaries “Stat Profile Critical Care Express Capillary Tube 230 µL with Na Heparin” LOT 107669, СО2 chamber.
Results. In the course of studying the products of outgassing of polymer materials using an exposure chamber and a gas chromatomass spectrometer, a significant increase in toxicity (4.8 times) of a mixture of chemicals released from epoxy glue EK-5T during the transition from thermal-oxidative decomposition (smoldering) to flame combustion was established. The toxicity index of the combustion products of the ELPLAST-180ID compound under the same conditions increases by 1.8 times. A linear dependence of the percentage of lethality of laboratory animals on the integral indicator of the toxicity of combustion products has been established.
Limitations. Studies of the toxicity of combustion products were carried out on non-metallic materials: epoxy glue EK-5T, compound ELPLAST-180ID. These materials are planned to be used in hermetically sealed objects of the Navy.
Conclusion. The expediency of using gas chromatography-mass spectrometry for assessing the combined effect of combustion products is shown.
About the authors
Maxim Fedorovich Shishonok
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Author for correspondence.
Email: 8ambulance@mail.ru
Junior researcher FSUE "Research Institute of Hygiene, Occupational Pathology and Human Ecology", FMBA of Russia, g.p. Kuzmolovskii, 188663, Leningrad region, Russian Federation.
e-mail: 8ambulance@mail.ru
Russian FederationEvgenii Yrievich Karmanov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: karmanov@gpech.ru
Научный сотрудник лаборатории общей токсикологии и гигиенического регламентирования, ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, г.п. Кузьмоловский, Ленинградская область, Российская Федерация.
e-mail: Karmanov@gpech.ru
Russian FederationAnton Igorevich Ukolov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: ukolov.ai@gpech.ru
ORCID iD: 0000-0002-2911-1260
Заместитель заведующего отделом токсикологии, ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, г.п. Кузьмоловский, Ленинградская область, Российская Федерация.
e-mail: ukolov.ai@gpech.ru
Russian FederationAlexander Vasilyevich Zemlyanoi
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: zemlianoi@gpech.ru
ORCID iD: 0000-0001-8055-2291
Заведующий лабораторией общей токсикологии и гигиенического регламентирования, ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, г.п. Кузьмоловский, Ленинградская область, Российская Федерация.
e-mail: zemlianoi@gpech.ru
Russian FederationNataliya Viktorovna Yerunova
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: nat-erunova@mail.ru
Ведущий научный сотрудник лаборатории общей токсикологии и гигиенического регламентирования, ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, г.п. Кузьмоловский, Ленинградская область, Российская Федерация.
e-mail: nat-erunova@mail.ru
Russian FederationAnatolii Ivanovich Nikolaev
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: ainikolaev1956@gmail.com
ORCID iD: 0000-0002-6223-8589
Старший научный сотрудник лаборатории общей токсикологии и гигиенического регламентирования, ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, г.п. Кузьмоловский, Ленинградская область, Российская Федерация.
e-mail: ainikolaev1956@gmail.com
Russian FederationViktor Konstantinovich Borodavko
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: borodavko@gpech.ru
Старший научный сотрудник лаборатории общей токсикологии и гигиенического регламентирования, ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, г.п. Кузьмоловский, Ленинградская область, Российская Федерация.
e-mail: borodavko@gpech.ru
Russian FederationSergey Anatolyevich Dulov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: dulov@gpech.ru
Заместитель директора по научной работе ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, г.п. Кузьмоловский, Ленинградская область, Российская Федерация.
e-mail: dulov@gpech.ru
Russian FederationAndrey Stanislavovich Radilov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: radilov@gpech.ru
ORCID iD: 0000-0002-6223-8589
И.о. директора ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, г.п. Кузьмоловский, Ленинградская область, Российская Федерация.
e-mail: radilov@gpech.ru
Russian FederationReferences
- https://www.mchs.gov.ru/deyatelnost/press-centr/novosti/4359846
- Ilichkin V.S. Toxicity of combustion products of polymeric materials: Principles and methods of determination [Toksichnost` produktov goreniya polimerny`x materialov: Principy` i metody` opredeleniya]. St. Petersburg: Chemiya; St. Petersburg Publishing House, 1993. (in Russian)
- Grebenyuk A.N., Bykov V.N., Carbon monoxide: modern approaches to the treatment of acute poisoning. Toksikologicheskii vestnik. 2021; 5: 17–24. (in Russian)
- Gakhnapetyan A.P. Forensic aspects of poisoning by combustion products of polymer materials [Sudebno-medicinskie aspekty` otravlenij produktami goreniya polimerny`x materialov]. Abstract of the dissertation of the Candidate of Medical Sciences. 1997. (in Russian)
- Gladkikh V.D. Ivanov M.B. Combustion products toxicology. Clinical and experimental aspects [Toksikologiya produktov goreniya. Kliniko-e`ksperimental`ny`e aspekty. FSUE SPC “Farmzashchita” FMBA of Russia. Moscow: 2020. (in Russian)
- Tiunov L.A., Kustov V.V. Toxicology of carbon monoxide [Toksikologiya okisi ugleroda]. Moscow: Medicine; 1980. (in Russian)
- GOST 12.1.044-89. The system of occupational safety standards. Fire and explosion hazard of substances and materials. Date of introduction 01.01.1991. (in Russian)
- Ilichkin V.S., Smirnov N.V., Eliseev Yu.N., Belousov Yu.Y., Zaitsev A.A., Komova M.A. Determination of the toxicity index of combustion products of materials by experimental calculation method [Opredelenie pokazatelya toksichnosti produktov goreniya materialov e`ksperimental`no-raschetny`m metodom]. Pozharovzry`vobezopasnost. 2005. (in Russian)
- GOST 12.1.007-76 System of occupational safety standards. Harmful substances. Classification and general safety requirements. Date of introduction 01.01.1977. (in Russian)
Supplementary files
