Email this article The relationship of hemorheological disorders with the development of endotoxicosis in the rehabilitation period of acute poisoning
- Authors: Goldfarb Y.S.1,2, Yelkov A.N.1,2, Badalyan A.V.1,2, Potshveriya M.M.1,2, Bitkova E.E.1
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Affiliations:
- Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
- Russian Medical Academy of Postgraduate Education, Public Educational Institution of Additional Professional Postgraduate Education of Russian Federation Healthcare Ministry
- Issue: No 1 (2023)
- Pages: 4-17
- Section: Original articles
- Published: 23.02.2023
- URL: https://clinpractice.ru/0869-7922/article/view/641473
- DOI: https://doi.org/10.47470/0869-7922-2023-31-1-4-17
- ID: 641473
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Abstract
The aim of the study. Obtaining new data on the pathogenesis of endotoxicosis (ET) in the rehabilitation period of acute poisoning by assessing the conjugacy of hemorheology (HR) disorders with the development of ET.
Material and methods. To obtain new information about the pathogenesis of acute poisoning in the rehabilitation period in 145 patients with severe acute poisoning with psychopharmacological agents (PFAp) due to the addition of pneumonia, neurotoxicants (NTp) with the development of toxic hypoxic encephalopathy and corrosive substances (CSp) with deep and widespread burns of the mucous membranes of the gastrointestinal tract, a pair correlation analysis of the block structure of the obtained correlation matrix was undertaken, establishing the relationship between the two indicators, as well as a canonical correlation analysis revealing the nature of the statistical relationship between groups of indicators, with the calculation of the canonical correlation coefficient.
Results. As a result, statistically significant correlations were established between the indicators HR (viscometric, aggregation and indicators hemostasis) and ET (total and effective albumin concentration, the level of medium molecular weight peptides, the content of leukocytes, lymphocytes, neutrophils and circulating immune complexes detected in the blood, and his integral indicators) (–0.32–0.48 for PFAp, 0.29–0.35 for NTp and 0.28–(–0.51) for CSp), as well as statistically significant values canonical correlation coefficients, which indicated the development of ET due to disorders of HR.
Limitations. The study was performed on laboratory data obtained during the examination of patients with acute poisoning, and therefore has no restrictions for the further use of this methodological approach in clinical trials.
Conclusion. The obtained data can serve to optimize the treatment of ET in this pathology by targeted therapeutic effects on parameters of HR (on viscosity and hemostasis in PFAp and NTp, and in CSp, in addition, on aggregation).
Compliance with ethical standards. The study does not require the submission of the opinion of the biomedical ethics committee or other documents.
Contribution of the authors:
Goldfarb Yu.S. — concept and design of the study, writing and editing of the text of the article, interpretation of the results of the study, coordination of the actions of the author’s team;
Elkov A.N. — mathematical processing of the material, interpretation of the results of the study;
Badalyan A.V. — examination of patients within the framework of the study design, participation in the writing and editing of the article;
Potshveriya M.M. — editing the text of the article, participation in the interpretation of the received data;
Bitkova E.E. — performing the laboratory part of the study within the framework of the study design, processing and interpretation of laboratory data.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.
Conflict of interests. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Received: May 05, 2023 / Accepted: 2022 / Published: February 28, 2023
About the authors
Yuriy Semenovich Goldfarb
Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department; Russian Medical Academy of Postgraduate Education, Public Educational Institution of Additional Professional Postgraduate Education of Russian Federation Healthcare Ministry
Author for correspondence.
Email: goldfarbjs@sklif.mos.ru
ORCID iD: 0000-0002-0485-2353
Doctor of Sciences (Medicine), Full Professor, Head of the Department of External Scientific Relations, Researcher of the Department of Acute Poisoning and Somatopsychiatric Disorders of the N.V. Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow, 129090, Moscow, Russian Federation; Head of the Department of Clinical Toxicology of Russian Medical Academy of Postgraduate Education, Public Educational Institution of Additional Professional Postgraduate Education of Russian Federation Healthcare Ministry, 125993, Moscow, Russian Federation.
e-mail: GoldfarbJS@sklif.mos.ru
Russian FederationAleksandr Nikonorovich Yelkov
Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department; Russian Medical Academy of Postgraduate Education, Public Educational Institution of Additional Professional Postgraduate Education of Russian Federation Healthcare Ministry
Email: elkovan@sklif.mos.ru
ORCID iD: 0000-0002-5945-503X
Кандидат физико-математических наук, старший научный сотрудник отделения лечения острых отравлений и соматопсихиатрических расстройств Государственного бюджетного учреждения здравоохранения города Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы», сотрудник кафедры клинической токсикологии Федерального государственного бюджетного образовательного учреждения дополнительного профессионального образования «Российская медицинская академия последипломного образования», 129090, г. Москва, Российская Федерация.
e-mail: ElkovAN@sklif.mos.ru
Russian FederationAmayak Vazgenovich Badalyan
Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department; Russian Medical Academy of Postgraduate Education, Public Educational Institution of Additional Professional Postgraduate Education of Russian Federation Healthcare Ministry
Email: badalianav@sklif.mos.ru
ORCID iD: 0000-0003-4429-2503
Доктор медицинских наук, заведующий отделением лечения острых отравлений Государственного бюджетного учреждения здравоохранения города Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы», доцент кафедры клинической токсикологии Федерального государственного бюджетного образовательного учреждения дополнительного профессионального образования «Российская медицинская академия последипломного образования», 125993, г. Москва, Российская Федерация.
e-mail: BadalianAV@ sklif.mos.ru
Russian FederationMikhail Mikhailovich Potshveriya
Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department; Russian Medical Academy of Postgraduate Education, Public Educational Institution of Additional Professional Postgraduate Education of Russian Federation Healthcare Ministry
Email: potskhveriyamm@sklif.mos.ru
ORCID iD: 0000-0003-0117-8663
Кандидат медицинских наук, заведующий научным отделением острых отравлений и соматопсихиатрических расстройств Государственного бюджетного учреждения здравоохранения города Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы», доцент кафедры клинической токсикологии Федерального государственного бюджетного образовательного учреждения дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования», 129090, г. Москва, Российская Федерация.
e-mail: PotskhveriyaMM@sklif.mos.ru
Russian FederationElena Evgenyevna Bitkova
Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
Email: bitkovaee@sklif.mos.ru
ORCID iD: 0000-0001-6066-830X
Кандидат медицинских наук, старший научный сотрудник лаборатории трансфузиологии, консервирования тканей и искусственного питания Государственного бюджетного учреждения здравоохранения города Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы», 129090, г. Москва, Российская Федерация.
e-mail: BitkovaEE@sklif.mos.ru
Russian FederationReferences
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