The role of bioactive agents in enhancing the defense response to nanoparticle toxicity (a literature review)

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Abstract

Introduction. Ubiquity of nanoparticles (NPs) necessitates the increase in the resistance and tolerance of the human body to their toxic effects. The exposure to nanoparticles can occur not only in the occupational setting but also because of environmental pollution and a purposeful use of nanomaterials (e.g., in medicine and cosmetology). Impossibility of elimination of nanoparticle exposure and its adverse health effects at the current stage of technological development makes the problem even more urgent. Our objective was to study the ability of bioactive agents (vitamins, macro- and microelements, flavonoids, etc.) to enhance the defense response to nanoparticle toxicity. 

Material and methods. The analysis and generalization of modern scientific research is carried out. To review and summarize data of recent scientific studies, we have done a literature search using PubMed, Web of Science, and Google Scholar search engines, as well as Russian scientific electronic libraries eLibrary.ru and Cyberleninka.ru. The inclusion criteria were information about adverse health effects of nano-sized particles (1–100 nm) and attenuation of their toxicity using bioprotectors in experimental animals. After primary screening of more than 70 publications, we selected thirty-six articles for the review.

Results. The ability of bioactive agents to increase the resistance of a living organism, including warm-blooded mammals, to nanoparticle exposure has been demonstrated. We established a protective effect of vitamin E against nephrotoxicity of gold NPs and toxicity of silver NPs; vitamin C against the hepatotoxic effect of titanium (IV) oxide NPs and reproductive toxicity of nickel NPs, and B vitamins against toxic effects of zinc oxide NPs. We have also found evidence of a protective effect of selenium against silver NPs, including cardioprotective ones. Flavonoids (hesperidin and quercetin) demonstrated protective effects against nephro-, neuro- and hepatotoxicity of nanoparticles. In addition, we noted their positive role in repair of mitochondrial dysfunction. L-arginine also showed the ability to attenuate poisoning induced by Au NPs.

Limitations of the study. We reviewed open access Russian and English-language publications.

Conclusion. This literature review facilitates identification of the most effective ways to increase the resistance and tolerance of a living organism to adverse health effects of nanoparticles.

Compliance with ethical standards. This study does not require the conclusion of a biomedical ethics committee or other documents.

Author Contribution:
Ryabova Yu.V. — study conception and design, draft manuscript preparation;
Shabardina L.V. — data collection and processing. Both authors reviewed the results and approved the final version of the manuscript.

Conflict of interests. The authors declare no conflict of interest. 

Acknowledgements. the study was carried out at the expense of the budget of the Federal State Budgetary Institution "Yekaterinburg Medical and Scientific Center for Prevention and Health Protection of Industrial Workers" of Rospotrebnadzor.

Received: January 16, 2023 / Accepted: February 9,2023 / Published: April 30, 2023

About the authors

Yulia Vladimirovna Ryabova

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Author for correspondence.
Email: ryabovaiuvl@gmail.com
ORCID iD: 0000-0003-2677-0479

Head of the Laboratory of Scientific Fundamentals of Biological Methods of Disease Prevention, Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Yekaterinburg, 620014, Russian Federation.

e-mail: ryabovaiuvl@gmail.com

Russian Federation

Lada Vladimirovna Shabardina

Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Email: lada.shabardina@mail.ru
ORCID iD: 0000-0002-8284-0008
Russian Federation

References

  1. Manke A., Wang L., Rojanasakul Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int. 2013; 2013: 942916. https://doi.org/10.1155/2013/942916
  2. Hedayati S.A., Farsani H.G., Naserabad S.S., Hoseinifar S.H., Van Doan H. Protective effect of dietary vitamin E on immunological and biochemical induction through silver nanoparticles (AgNPs) inclusion in diet and silver salt (AgNO3) exposure on Zebrafish (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol. 2019; 222: 100–7. https://doi.org/10.1016/j.cbpc.2019.04.004
  3. Bakr M.M., Al-Ankily M.M., Shogaa S.M., Shamel M. Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands. Bioengineering (Basel). 2021; 8(12): 219. https://doi.org/10.3390/bioengineering8120219
  4. Abdelhalim M.A.K., Qaid H.A., Al-Mohy Y.H., Ghannam M.M. The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles. Int J Nanomedicine. 2020; 15: 729–34. https://doi.org/10.2147/IJN.S192740
  5. Baky N.A., Faddah L.M., Al-Rasheed N.M., Al-Rasheed N.M., Fatani A.J. Induction of inflammation, DNA damage and apoptosis in rat heart after oral exposure to zinc oxide nanoparticles and the cardioprotective role of α-lipoic acid and vitamin E. Drug Res (Stuttg). 2013; 63(5): 228–36. https://doi.org/10.1055/s-0033-1334923
  6. Kalender S., Kalender Y., Ogutcu A., Uzunhisarcikli M., Durak D., Açikgoz F. Endosulfan-induced cardiotoxicity and free radical metabolism in rats: the protective effect of vitamin E. Toxicology. 2004; 202(3): 227–35. https://doi.org/10.1016/j.tox.2004.05.010
  7. Hajirezaee S., Mohammadi G., Naserabad S.S. The protective effects of vitamin C on common carp (Cyprinus carpio) exposed to titanium oxide nanoparticles (TiO2-NPs). Aquaculture. 2020; 518: 734734. https://doi.org/10.1016/j.aquaculture.2019.734734
  8. Taghyan S.A., Messiry H.E., Zainy M.A.E. Evaluation of the toxic effect of silver nanoparticles and the possible protective effect of ascorbic acid on the parotid glands of albino rats: аn in vivo study. Toxicol Ind Health. 2020; 36(6): 446–53. https://doi.org/10.1177/0748233720933071
  9. Kong L., Hu W., Lu C., Cheng K., Tang M.. Mechanisms underlying nickel nanoparticle induced reproductive toxicity and chemo-protective effects of vitamin C in male rats. Chemosphere. 2019; 218: 259–65. https://doi.org/10.1016/j.chemosphere.2018.11.128
  10. Hafez A.A., Naserzadeh P., Ashtari K., Mortazavian A.M., Salimi A. Protection of manganese oxide nanoparticles-induced liver and kidney damage by vitamin D. Regul Toxicol Pharmacol. 2018; 98: 240–4. https://doi.org/10.1016/j.yrtph.2018.08.005
  11. Yousef J.M., Mohamed A.M. Prophylactic role of B vitamins against bulk and zinc oxide nano-particles toxicity induced oxidative DNA damage and apoptosis in rat livers. Pak J Pharm Sci. 2015; 28(1): 175–84.
  12. Ansar S., Abudawood M., Hamed S.S., Aleem M.M. Sodium selenite protects against silver nanoparticle-induced testicular toxicity and inflammation. Biol Trace Elem Res. 2017; 175(1): 161–8. https://doi.org/10.1007/s12011-016-0759-3
  13. Ansar S., Alshehri S.M., Abudawood M., Hamed S.S., Ahamad T. Antioxidant and hepatoprotective role of selenium against silver nanoparticles. Int J Nanomedicine. 2017; 12: 7789–97. https://doi.org/10.2147/IJN.S136748
  14. Ma W., He S., Ma H., Jiang H., Yan N., Zhu L., Bang J.J., Li P.A., Jia S. Silver nanoparticle exposure causes pulmonary structural damage and mitochondrial dynamic imbalance in the rat: protective effects of sodium selenite. Int J Nanomedicine. 2020; 15: 633–45. https://doi.org/10.2147/IJN.S232986
  15. Ma W., He S., Xu Y., Qi G., Ma H., Bang J.J., Li P.A. Ameliorative effect of sodium selenite on silver nanoparticles-induced myocardiocyte structural alterations in rats. Int J Nanomedicine. 2020; 15: 8281–92. https://doi.org/10.2147/IJN.S271457
  16. Abdelhalim M.A.K., Moussa S.A.A., Qaid H.A.Y. The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats. Int J Nanomedicine. 2018; 13: 2821–5. https://doi.org/10.2147/IJN.S160995
  17. Abdelhalim M.A.K., Qaid H.A., Al-Mohy Y., Al-Ayed M.S. Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo. Int J Nanomedicine. 2018; 13: 7765–70. https://doi.org/10.2147/IJN.S183281
  18. Fadda L.M., Hagar H., Mohamed A.M., Ali H.M. Quercetin and idebenone ameliorate oxidative stress, inflammation, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in rat liver. Dose Response. 2018; 16(4). https://doi.org/10.1177/1559325818812188
  19. Al-Rasheed N.M., Faddah L.M., Mohamed A.M., Abdel Baky N.A., Al-Rasheed N.M., Mohammad R.A. Potential impact of quercetin and idebenone against immuno- inflammatory and oxidative renal damage induced in rats by titanium dioxide nanoparticles toxicity. J Oleo Sci. 2013; 62(11): 961–71. https://doi.org/10.5650/jos.62.961
  20. Waseem M., Kaushik P., Dutta S., Chakraborty R., Hassan M.I., Parvez S. Modulatory role of quercetin in mitochondrial dysfunction in titanium dioxide nanoparticle-induced hepatotoxicity. ACS Omega. 2022; 7(4): 3192–202. https://doi.org/10.1021/acsomega.1c04740
  21. Dora M.F., Taha N.M., Lebda M.A., Hashem A.E., Elfeky M.S., El-Sayed Y.S., Jaouni S.A., El-Far A.H. Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats. Int J Mol Sci. 2021; 22(8): 3829. https://doi.org/10.3390/ijms22083829
  22. Noshy P.A., Khalaf A.A.A., Ibrahim M.A., Mekkawy A.M., Abdelrahman R.E., Farghali A., Tammam A.A., Zaki A.R. Alterations in reproductive parameters and steroid biosynthesis induced by nickel oxide nanoparticles in male rats: The ameliorative effect of hesperidin. Toxicology. 2022; 473: 153208. https://doi.org/10.1016/j.tox.2022.153208
  23. Tammam A.A.-E., Khalaf A.A.А., Zaki A.R., Khalifa M.M., Ibrahim M.A., Mekkawy A.M., Abdelrahman R.E., Farghali A., Noshy P.A. Hesperidin protects rats’ liver and kidney from oxidative damage and physiological disruption induced by nickel oxide nanoparticles. Front Physiol. 2022; 13: 912625. https://doi.org/10.3389/fphys.2022.912625
  24. Ansar S., Abudawood M., Alaraj A.S.A., Hamed S.S. Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress. BMC Pharmacol Toxicol. 2018; 19(1): 65. https://doi.org/10.1186/s40360-018-0256-8
  25. Privalova L.I., Sutunkova M.P., Minigaliyeva I.A., Klinova S.V., Ryabova Iu.V., Solovyova S.N., Bushueva T.V., Fröhlich E., Shur V.Ya., Zubarev I.V., Makeyev O.H., Valamina I.E., Panov V.G., Shishkina E.V., Gurvich V.B., Katsnelson B.A. Experimental assessments of metallic and metal oxide nanoparticles’ toxicity. IOP Conf. Ser.: Mater. Sci. Eng. 2019; 699: 012037. https://doi.org/10.1088/1757-899X/699/1/012037
  26. Privalova L.I., Ryabova Yu.V., Sutunkova M.P., Gurvich V.B., Minigalieva I.A., Bushueva T.V., Tazhigulova A.V., Solovyеva S.N., Katsnelson B.A. Prevention of the combined cytotoxic effect of selenium and copper oxide nanoparticles in the аnimal еxperiment. Zdorov’e naseleniya i sreda obitaniya – ZNiSO. 2022; (9): 43–8. https://doi.org/10.35627/2219-5238/2022-30-9-43-48 (in Russian)
  27. Abdelazeim S.A., Shehata N.I., Aly H.F., Shams S.G.E. Amelioration of oxidative stress-mediated apoptosis in copper oxide nanoparticles-induced liver injury in rats by potent antioxidants. Sci Rep. 2020; 10(1): 10812. https://doi.org/10.1038/s41598-020-67784-y
  28. Faddah L.M., Abdel Baky N.A., Al-Rasheed N.M., Al-Rasheed N.M., Fatani A.J., Atteya M. Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. BMC Complement Altern Med. 2012; 12: 60. https://doi.org/10.1186/1472-6882-12-60
  29. Moradi A., Ziamajidi N., Ghafourikhosroshahi A., Abbasalipourkabir R. Effects of vitamin A and vitamin E on attenuation of titanium dioxide nanoparticles-induced toxicity in the liver of male Wistar rats. Mol Biol Rep. 2019; 46(3): 2919–32. https://doi.org/10.1007/s11033-019-04752-4
  30. Afshari-Kaveh M., Abbasalipourkabir R., Nourian A., Ziamajidi N. The protective effects of vitamins a and e on titanium dioxide nanoparticles (nTiO2)-induced oxidative stress in the spleen tissues of male Wistar rats. Biol Trace Elem Res. 2021; 199(10): 3677–87. https://doi.org/10.1007/s12011-020-02487-z
  31. Abdelazim A.M., Saadeldin I.M., Swelum A.A., Afifi M.M., Alkaladi A. Oxidative stress in the muscles of the fish nile tilapia caused by zinc oxide nanoparticles and its modulation by vitamins C and E. Oxid Med Cell Longev. 2018; 2018: 6926712. https://doi.org/10.1155/2018/6926712
  32. Alkaladi A. Vitamins E and C ameliorate the oxidative stresses induced by zinc oxide nanoparticles on liver and gills of Oreochromis niloticus. Saudi J Biol Sci. 2019; 26(2): 357–62. https://doi.org/10.1016/j.sjbs.2018.07.001
  33. Abdelhalim M.A.K., Moussa S.A.A., Qaid H.A., Al-Ayed M.S. Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles. Int J Nanomedicine. 2018; 13: 7931–8. https://doi.org/10.2147/IJN.S171931
  34. Al-Rasheed N.M., Al-Rasheed N.M., Abdel Baky N.A., Faddah L.M., Fatani A.J., Hasan I.H., Mohamad R.A. Prophylactic role of α-lipoic acid and vitamin E against zinc oxide nanoparticles induced metabolic and immune disorders in rat’s liver. Eur Rev Med Pharmacol Sci. 2014; 18(12): 1813–28.
  35. Abdelkarem H.M., Fadda L.H., El-Sayed E.M., Radwan O.K. Potential role of L-arginine and vitamin E against bone loss induced by nano-zinc oxide in rats. J Diet Suppl. 2018; 15(3): 300–10. https://doi.org/10.1080/19390211.2017.1343889
  36. Mohamed A.S., Soliman H.A., Ghannam H.E. Ameliorative effect of vitamins (E and C) on biochemical alterations induced by sublethal concentrations of zinc oxide bulk and nanoparticles in Oreochromis niloticus. Comp Biochem Physiol C Toxicol Pharmacol. 2021; 242: 108952. https://doi.org/10.1016/j.cbpc.2020.108952

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