Time scale of adaptation at the tonal sequence processing in the awake mice auditory cortex neurons

Мұқаба

Дәйексөз келтіру

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Рұқсат жабық Тек жазылушылар үшін

Аннотация

The study was firstly carried out on stimulus-specific adaptation of neurons in the primary and anterior fields of the awake house mice auditory cortex to sound sequences of four 100-ms tonal signals, with frequency of tones corresponding to the neuronal characteristic frequency, and also with the inter-tone interval constant for one sequence and varying from 0 to 2000 ms in different sequences. The analysis of the data obtained showed the adaptation effect in the responses of all studied primary auditory cortex neurons, which was observed as the absence or significant decrease in activity evoked by the components of a series of tones following the 1st, at inter-stimulus intervals of 0–500 ms. A quantitative assessment of the adaptation effects as a function of inter-stimulus intervals within the tonal sequence, performed over whole population of studied neurons, showed that the individual time scales of adaptation of neurons varied significantly, which may be crucial for the formation of optimal time windows for the processing of grouping and separation of sound events, which are important both for perception of animal vocalizations and human speech.

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Авторлар туралы

М. Egorova

Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: ema6913@yandex.ru
Ресей, Saint Petersburg

А. Akimov

Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences

Email: ema6913@yandex.ru
Ресей, Saint Petersburg

G. Khorunzhii

Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences

Email: ema6913@yandex.ru
Ресей, Saint Petersburg

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2. Fig. 1. Examples of the activity of two neurons in the auditory cortex of an awake mouse with different temporal dynamics of adaptation (a, b). In the upper part of the figure are peristimulus histograms of neuronal responses evoked by series of tones with different interstimulus intervals. The value of the interstimulus interval for each series is indicated by numbers on the diagram. The number of signal repetitions is 20. The bin size is 2 ms. Abscissa – time, ms. The ordinate is the number of spikes, N. Under each histogram there is a mark of the stimulus, which is a series of 4 tones with a duration of 100 ms each. In the lower part of the figure is the dependence of the magnitude of the response of the same neurons to the 2nd, 3rd and 4th signals of the series on the interpulse interval (response recovery curves). The magnitude of the neuron’s response to the 2–4th signal of the series (the number of spikes) is normalized relative to its response to the 1st signal, i.e., it is equal to the ratio of the number of spikes in the neuron’s response to the corresponding signal to the number of spikes in the response to the 1st signal.

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3. Fig. 2. Normalized functions of restoration of responses to the 2nd, 3rd and 4th signals of the series, averaged over 39 neurons. The standard deviations of the average responses of neurons to the corresponding tones of the series are indicated. Other designations are as in Fig. 1.

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4. Fig. 3. Temporal dynamics of adaptation to series of near-threshold signals. (a) Peristimulus histograms of responses of a single neuron evoked by series of tones with different interstimulus intervals. The value of the interstimulus interval for each series is indicated by numbers on the diagram. The number of signal repetitions is 20. The bin size is 2 ms. The time window for data analysis is 6.4 s. Abscissa – time, c. Ordinate – number of spikes, N. Below each histogram is a stimulus mark, which is a series of 4 tones each lasting 100 ms. (b) – Dependence of the number of spikes in the response of a single neuron to the 1st, 2nd, 3rd and 4th signals of the series on the interstimulus interval. Abscissa – time, ms. Ordinate – number of spikes, N. (c) – Normalized functions for reconstructing the responses of a single neuron to the 2nd, 3rd and 4th signals of the series; (d) – Normalized reconstruction functions of responses to the 2nd, 3rd and 4th signals of the series, averaged over 8 neurons. The standard deviations of the average responses of neurons to the corresponding tones of the series are indicated. Other designations are as in Fig. 1.

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