Volgograd Journal of Medical Research
Quarterly, peer-reviewed scientific journal.
Editor-in-Chief
- Sergey V. Dmitrienko, Doctor of Medical Sciences, Professor, PhD
Publisher
- Publishing house of the Volgograd State Medical University
Founders
- Publishing house of the Volgograd State Medical University
Indexing
- Russian Science Citation Index (RSCI)
- Google Scholar
Frequency
- 4 issues per year
About journal
The "Volgograd Scientific Medical Journal" accepts scientific papers in the form of articles, reflecting the results of completed fundamental and practical scientific research, corresponding to the profile of the journal. The main headings of the scientific publication are: scientific reviews, scientific articles (original studies), scientific reviews, reviews on the following scientific specialties: public health and healthcare organization, sociology and history of medicine, dentistry, internal medicine, surgery, pharmacology, clinical pharmacology, pathological anatomy , human anatomy, hygiene, restorative medicine, sports medicine, exercise therapy, balneology and physiotherapy.
Main headings
- Clinical medicine
- Health sciences
- Medical biotechnology
- Dentistry
- Pharmacology, clinical pharmacology
- Public health, organization and sociology of healthcare
Current Issue
Vol 22, No 3 (2025)
- Year: 2025
- Published: 05.10.2025
- Articles: 11
- URL: https://clinpractice.ru/2658-4514/issue/view/14023
Full Issue
Articles
Study of electromyographic indices in patients with small unilateral terminal defects
Abstract
Today, there is a need for detailed study of muscular activity features in patients with small unilateral terminal dental defects. Modern prosthetic methods require assessment of their effectiveness in terms of restoring symmetric functioning of the masticatory apparatus. Aim of the study. To analyze electromyographic indices in patients with small unilateral terminal defects using various prosthesis designs: small saddle-shaped and clasp-fixed partial dentures, as well as traditional removable laminar dentures. Materials and methods. The study includes a prospective electromyographic examination of 77 patients divided into the main group (n = 40) and the control group (n = 37) with statistical processing. Surface electromyographic examination of the masticatory and temporal muscles on both sides was conducted at stages: before treatment, after 1 month, and 6 months after prosthetics using the “Kolibri” apparatus (Neurotech). Results and discussion. Statistically significant differences in muscle electromyography were obtained when using different prosthesis designs. The greatest changes were observed in groups with original prostheses, indicating more physiological masticatory load transmission. The increase in biopotential indices of the masticatory and temporal muscles ranged from 18.2 to 28.4 % in the main group compared to the control group. Conclusion. The study demonstrates the effectiveness of original prosthesis designs with clasp fixation, providing more physiological functioning of the masticatory muscles. The obtained results emphasize the importance of an individual approach to selecting the prosthetic method, taking into account the patient’s physiological characteristics and prosthesis design.



Analgesic activity of the new A1/A2a agonist, the Cl–Ala-OH-AR compound
Abstract
In this study, the analgesic activity of the Cl-Ala-OH-AR compound was evaluated in various models of somatogenic somatic pain. The results showed that the Cl-Ala-OH-AR compound significantly increases the latency of the reaction in tests of the formation of thermal somatic pain, such as "Hot plate" and "Tail Twitching", however, its effectiveness was lower than that of tramadol and adenosine. In the algogen-induced somatic pain model evaluated in the formalin test, Cl-Ala-OH-AR demonstrated more pronounced analgesic properties, especially in the inflammatory phase, where the reduction in pain reactions was 3.4 times greater than the effect of adenosine. These results indicate a significant analgesic potential of Cl-Ala-OH-AR in the context of somatogenic somatic pain caused by algogens, which opens up prospects for further study.



Ensure of epidemiological safety of premises of medical organizations
Abstract
Objective: to assess the microbial contamination of the air environment (MCAE) in the premises of medical organizations and the efficiency of the method for its reduction. Research methods. A device for air conditioning o a closed room has been developed, which prevents the ingress of bacteria into the air and has a bactericidal effect. A solution of lithium chloride was used as the active substance. The content of lithium chloride with the device in operation was determined. The influence of bischofite as an active substance on the microbial contamination of the air was studied. The microbial contamination of the air was assessed before and after the operation of the air conditioner. Research results. A decrease in the microbial contamination of the air was revealed after the operation of the air conditioning device when using both lithium chloride and bischofite as the active substance. At the same time, no hazardous concentrations of substances for humans were detected in the air of the premises. Conclusion. The air conditioning device has shown high efficiency when operating in medical premises. At the same time, its design prevents the active substance from entering the environment, ensuring a reliable reduction in microbial contamination.



Once again, about awareness of vaccination issues
Abstract
Numerous ongoing studies on the credibility of vaccination highlight the increasing urgency of this issue. In this regard, it is very important to evaluate citizens' choice of sources of information about vaccinations and their preferences. Purpose. To study and analyze the problems and barriers preventing vaccinations, the attitude of the medical community and the population towards vaccination, as well as to identify reserves for increasing motivation for vaccination and public awareness of immunization with pneumococcal vaccines. Materials and methods. An anonymous survey of the population aged 18 and over was conducted in the number of 386 people and 378 medical workers of various specialties from 25 medical organizations of the state healthcare system of the Volgograd region. The survey was conducted between March and April 2025. The questionnaire included 3 blocks of questions and consisted of 24 questions for the public and 18 questions for medical professionals. The first block of questions contained the general passport part: gender, age, specialty, presence of children. The main part of the questions concerned the attitude to vaccinations, the reasons for agreeing or refusing vaccination. The final part of the questionnaires contained questions on the study o satisfaction and quality of the organization of medical care in the outpatient clinic during vaccinations. Results and discussion. The results of the survey showed that the population receives basic information about vaccination in medical organizations, where the main source of information about vaccination is a doctor. At the same time, 70.7 % of citizens trust and receive information about the need for vaccinations at the service area from medical professionals. Half of the surveyed citizens are insufficiently informed about vaccination issues. This indicates that there is a steady demand for more information on this issue, both from medical professionals and the public. Conclusion. In general, even with the noted lack of information, the population of the Volgograd region is positive about vaccination. The basic condition for carrying out vaccine prophylaxis, including each individual stage of it, before obtaining the consent of the patient or his legal representative, is to inform. The results of the survey showed a steady demand for information on vaccination with pneumococcal vaccines, both from medical professionals and the population. In order to form a commitment to vaccination, the patient or his legal representative must be informed in detail about the immunization process itself, as well as about possible adverse events after vaccination, and its main advantages. The information should be provided in an accessible form, and the patient should be given full, detailed answers to all questions he or she may have during his or her appointment at the clinic/FOS.



The role of value orientations of a general practitioner (district physician) as an element of the position profile
Abstract
The effectiveness of a district general practitioner (DGP) largely depends on their value orientations and their attachment to the workplace. New opportunities for diagnosing personal traits at the stage of selection and recruitment of medical personnel demonstrate their usefulness and potential for effective application. The number of publications confirming the influence of an employee’s personality traits on the selection and recruitment process, as well as on the quality of their work – including among district general practitioners – is increasing. The aim of this study is to examine the most important value orientations for DGPs as an element of the medical job profile, using the example of district general practitioners at the State Healthcare Institution "Polyclinic No. 2" in Volgograd. Materials and Methods. Value orientations in the careers of district general practitioners at the State Healthcare Institution "Polyclinic No. 2" were studied within the framework of medical job profiling. Edgar Schein’s Career Anchors methodology was used for the study. A survey was conducted involving 35 specialists from the medical organization. Results and Discussion. The dominant career anchors among the group of doctors were "service" and "lifestyle integration". The main values within the "service" anchor included "working with people", "serving humanity", "helping people", and "the desire to make the world a better place", which define commitment to the profession, love and patience towards patients, as well as the specifics of the therapeutic and diagnostic process in the role of a district general practitioner. Conclusion. The intensive and demanding work of a district general practitioner requires the development of appropriate professional and personal skills during the adaptation process. The success of this process is largely possible due to the career anchors of "service", "lifestyle integration", "professional competence", and "autonomy" at the early stages of professional development of young specialists.



An analytical review of the angular parameters of a face with different types of height according to telerentgenography data
Abstract
The analysis of the angular parameters of telerentgenograms aimed at determining the typological variants o the facial region of the head is still relevant and requires additions and improvements. Goal. To conduct a comparative analysis of various methods for determining the types of facial growth, including author's additions, in the physiology and pathology of occlusion on a telerentgenogram in lateral projection. Materials and methods. The retrospective study included the analysis of 46 telerentgenograms with physiological occlusion and 23 images with dental-alveolar and gnatic malocclusion. Traditional research methods were used in the analysis. The parameters of the total Bjork angle, the Ricketts facial angle, the lower gonial angle, and the angles determining the position of the mandibular plane to the base of the skull and the base of the upper jaw were determined. The analysis used a generally accepted sectoral chart of the types of facial head growth. Results and discussion. The total Bjork angle was (389.47 ± 1.46)°. The lower gonial angle was (71.26 ± 1.39)°. The facial angle of Ricketts in the whole group was (90.69 ± 0.72)°. The angle NSL-ML was (29.13 ± 1.28) degrees, and the angle NL-ML was (24.41 ± 1.64)°. All parameters were close to the neutral type of growth, however, significant variability of signs was determined. It was noted that the variability of the Bjork angle was usually determined by the magnitude of the mandibular angle, which varied from 110 to 128° during physiological occlusion. The results of the study made it possible to amend the data of the sectoral analysis of facial growth types and conduct a comparative study with generally accepted indicators. Conclusion. An analytical review of methods for assessing the typological features of a face allowed us to modify the sector diagram, which amended the ranges of variability of features and highlighted indicators of physiological and pathological variants of the type of facial growth. The proposed diagram can be used by orthodontists and maxillofacial surgeons when planning the treatment of occlusion anomalies associated with changes in the vertical parameters of the face and its main divisions.



Features of the angular parameters of the gnatic part of the face in different periods of ontogenesis, taking into account the variability of the mandibular angle
Abstract
The variability of the parameters of the maxillofacial region in cases of occlusion anomalies in the vertical direction requires improved diagnostic methods. Goal. To determine the features of the angular parameters of the gnatic part of the face in different periods of ontogenesis, taking into account the variability of the mandibular angle. Materials and methods. An analysis of 75 telerentgenograms was carried out, of which 59 cases showed physiological occlusion and 16 telerentgenograms with anomalies of occlusion in the vertical direction. The angle of the gnathic region of the face was estimated, formed by the intersection of the line connecting the point of the anterior nasal spine with the upper point of the articular head SNA-Cond and the line extending from the articular point to the tip of the root of the inferior medial incisor Cond-Api. The angle of the lower jaw and its component parts were measured. The statistical analysis determined the average values and the error M ± m. Results and discussion. As a result of the study of telerentgenograms of young people with physiological bite, the angle of the gnatic part of the face SNA-Cond-Api averaged (29.96 ± 0.84)° for the group. The magnitude of the main angle of the gnatic part of the face SNA-Cond-Api, both in the milk and in the changeable bite, was normally (30.02 ± 1.25)°. This indicator served as a guideline for the diagnosis of occlusion anomalies in the vertical direction, while the magnitude of the main angle differed from the optimal values up or down. During the analysis of telerentgenograms in various periods of ontogenesis, taking into account the parameters of the mandibular angle, the main parameters of the gnathic region of the face, characterizing its optimal angular parameters, were determined. Conclusion. The relative stability of the magnitude of the main angle of the gnathic part of the face SNA-Cond-Api in the range from 28 to 32° is characteristic of physiological occlusion and for dental-alveolar forms of occlusion anomalies. A change in the angle parameters to a lesser or greater side is characteristic of occlusion anomalies in the vertical direction, which can be used for the differential diagnosis of vertical anomalies of gnathicand dentoalveolar forms of pathology.



Immunohistochemical analysis of Klotho protein expression in the brain of aging rats with diabetes mellitus under pharmacological correction
Abstract
The Klotho protein is one of the key regulators of aging and metabolism in the brain of aging rats. The relevance of the work is due to the high prevalence of diabetic encephalopathy in elderly people with diabetes and the lack of knowledge of the mechanisms of its correction. Materials and methods. Type 1 diabetes was modeled on 36 Wistar rats at the age of 12 months by administration of streptozotocin. After 6 months of hyperglycemia, the animals received aminalon (1000 mg/kg/day) or succicard (50 mg/kg /day) for 30 days. The expression of Klotho protein in the retrosplenic cortex, hippocampus, thalamus, and hypothalamus was evaluated by immunohistochemistry. Quantitative analysis was performed using the ImageJ program, statistical significance was determined using ANOVA. Results and discussion. In rats with DM without treatment, lower levels of IRM expression using polyclonal antibodies against the Klotho protein were detected in the retrosplenic cortex, hippocampus, thalamus and hypothalamus, which, in comparison with intact animals, indicates a possible dysfunction of neuronal metabolism and a decrease in the protective activity of the Klotho protein in conditions of diabetic neurodegeneration. During aminalon therapy, the expression level of Klotho was higher than in animals without therapy. During Succicard therapy, Klotho levels exceeded those of the untreated group, but were inferior to aminalon. Conclusions. When modeling diabetes mellitus (DM), a decrease in the expression of immunoreactive material was noted when using antibodies against the Klotho protein in the retrosplenic cortex, hippocampus, thalamus and hypothalamus of rats, which indicates the appearance of signs of premature aging in brain structures against the background of triggering neuroinflammation processes, which contributes to the development of diabetic enephalopathy. During aminalon therapy, the expression level of the Klotho protein increased significantly. Treatment with succicard diabetes contributed to a less pronounced increase in the level of Klotho protein expression compared with aminalon. The results of the study confirm the prospects of searching for a number of GABA derivatives in diabetes, taking into account metabolic disorders in the Klotho/FGF 23 signaling pathway (fibroblast growth factor 23, fibroblast growth factor 23) in key cerebral structures.



Morphometric changes in the hippocampus and amygdala of mice in a model of chronic defeat stress
Abstract
Under the influence of chronic stress, including social stress, a person can develop borderline states and mental illnesses. The mechanisms and morphological substrate underlying them are studied using animal modeling, including the paradigm of chronic social defeat stress. However, there are poorly developed aspects and inconsistencies in the literature that require clarification. Objective. To study morphological changes in the hippocampus and amygdala during chronic social defeat stress modeling in mice in comparison with control animals. Materials and Methods. The study was conducted in the paradigm of "chronic social defeat stress" using the previously described technique on linear mice (CBA/lac). Upon completion of the experiment, brain micropreparations stained according to Nissl were studied with visual and morphometric assessment. Results. The obtained results confirm that the substructures of the hippocampus and amygdala participate in the body's reactions to chronic social stress, which is manifested in changes in the morphometric characteristics of neurons. In the CA1 field of the hippocampus, an increase in the density of neurons is observed with minor atrophy of the cells themselves, while in the CA3 field, hypertrophy of neurons is revealed, mainly due to an increase in the volume of the cytoplasm, with a decrease in the folding of the cellular and nuclear membranes against the background of a slight average decrease in the density of neurons. In the lateral, basolateral and basomedial nuclei of the amygdala, atrophic changes in neurons are noted, which are not accompanied by significant changes in their density. Conclusion. The described morphometric data are consistent with a number of functional and biochemical changes that can cause them. At the same time, there are discrepancies that require further comprehensive study of the issue from the point of view of the morphofunctional approach.



Morphometric variability of the maxillary sinus in various forms of facial skull
Abstract
Objective. To identify morphometric variability of the maxillary sinus in mesoprosopic and euryprosopic forms of facial skull using anatomical parameters. Materials and methods. A total of 144 computed tomograms of people in the second period of mature age were studied. Of these, 77 records of patients with the mesoprosopic form of facial skull and 67 tomograms with the euryprosopic form. The height and width of the maxillary sinus were measured on the tomograms. The indices of the ratio of the height and width of the maxillary sinus in the right-sided (IHWd) and left-sided (IHWs) sinuses, as well as the coefficient of relative symmetry of the maxillary sinuses were calculated. The SPSS Statistics 21.0 software product was used for statistical analysis. Results. The obtained parameter values demonstrate moderate variability with the highest variation coefficient in IHWd on male skulls with a mesoprosopic form. A higher value of IHWd compared to IHWs was found in male objects with the euryprosopic form. In people of both sexes, objects with asymmetric maxillary sinuses predominate with the mesoprosopic and leptoprosopic forms of the facial skull. Conclusion. Most parameters in the mesoprosopic form of the facial skull are higher than in the euryprosopic form. This is typical for the IHWs value in people of both sexes, and the IHWd values in women. The exception is the coefficient of relative symmetry of the sinuses in men, which prevails in the euryprosopic form of the facial skull.



Features of the Spee curve on radiographs and its changes in the treatment of patients with the "straight" arc technique
Abstract
Determining the features of the Spee occlusal curve is an urgent task in prosthetic dentistry and orthodontics. In most cases, the curvature of the occlusal plane is determined on plaster models of the jaws. At the same time, there is very little information about the methods of constructing the Spee occlusal curve on the TRG in the lateral projection. Purpose. To develop a method for constructing the Spee curve on a lateral telerentgenogram and to analyze it in people with physiological and pathological occlusion, as well as to evaluate the change in the occlusal curve in the treatment of patients with the "straight" arc technique. Materials and methods. The study was multifaceted and included the analysis of telerentgenograms and orthopantomograms of young people with physiological variants of the occlusal relationship of antagonists. This study was a retrospective cohort study. The distance between the anterior and posterior occlusal points through which the occlusal line passed was measured. Using PowerPoint programs, it was possible to draw a circle along the line of closure of the teeth through the occlusal points. The radius of the circle was measured. The ratio of the radius of the circle to the length of the sagittal size of the occlusal line was evaluated. The depth of the occlusal curve was measured from the point of the largest bulge to the occlusal line. The statistical analysis included the calculation of averages (M) and the error of representativeness (±m). Results and discussion. In the course of the analysis, a method was developed for constructing the Spee curve on the TRG in a lateral projection based on the proportionality of the sagittal size of the occlusal line, measured between the anterior and posterior occlusal points of the inferior dental arch and the radius of the occlusal circle. The radius exceeded the sagittal distance of the occlusal line by an amount corresponding to the Fibonacci number (1.618) and the golden ratio principle. The performed treatment with the "straight" arc technique contributed to the normalization of occlusal balance and the anterior teeth edge, however, it did not correspond to the optimal occlusal status characterizing physiological occlusion. Conclusion. The data obtained formed the basis for the differential diagnosis of physiological and pathological variants of the Spee curve. It should be noted that the treatment of patients with the "straight" (flat) arc technique, regardless of the severity of the Spee curve before treatment, does not correspond to achieving the optimal occlusal status characterizing physiological occlusion.


